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Abdominal Computed Tomography and the Blood Reactive Oxygen Species Level

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ClinicalTrials.gov Identifier: NCT00745641
Recruitment Status : Withdrawn (because of the presence of unexpected administrative barrier to interfere the collection of case)
First Posted : September 3, 2008
Last Update Posted : August 7, 2009
Sponsor:
Information provided by:
National Taiwan University Hospital

Brief Summary:

The clinically widely used X-ray computed tomography examination has a low-grade radiation effect and recently has attracted much attention concerning the possible adverse effects of radiation on human body [ref. 1-5]. The radiation is harmful to human tissues and cells mainly because it can interact with water (which makes up to 80% of cells) to generate reactive oxygen species (ROS), especially the formation of hydroxyl radicals. So far as we can reach, there is no report concerning the relation between X-ray computed tomography examination and the blood ROS level. Therefore, we wish to conduct this study to clarify if the routinely applied abdominal X-ray computed tomography examination may induce a higher level of ROS in the peripheral blood.

Study subjects will be patients who are admitted to our hospital because of abdominal diseases that need to receive abdominal X-ray computed tomography examination for diagnosis. In total, sixty cases will be enrolled for the study. The formal consent will be delivered and explained to the patients and families several hours before the performance of abdominal X-ray computed tomography. The formal consent will be retrieved and then the peripheral blood will be sampled just before the performance of computed tomography.ROS level in the sampled peripheral blood, before and after the performance of abdominal X-ray computed tomography, will be measured, compared, and analyzed. Totally 120 blood samples, including 60 samples just before and 60 samples 2 hours after the performance of computed tomography, will be collected from 60 study subjects within 5 months (August 10 ~ December 30, 2008). Reactive oxygen species(ROS)levels will be measured by a chemiluminescence (CL) analysing system (CLD-110, Tohoku Electronic Industrial, Sendai, Japan).


Condition or disease
Radiation Injury

Study Type : Observational
Estimated Enrollment : 60 participants
Observational Model: Case Control
Time Perspective: Prospective
Official Title: Effect of Abdominal X-ray Computed Tomography Examination on the Blood Reactive Oxygen Species Level
Study Start Date : September 2008
Estimated Primary Completion Date : December 2008
Estimated Study Completion Date : December 2008

Resource links provided by the National Library of Medicine


Group/Cohort
1
Sixty patients with abdominal illness and scheduled abdominal X-ray computed tomography examination will be included.



Biospecimen Retention:   None Retained
only peripheral blood will be collected for measurement of reactive oxygen species.


Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 80 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
patients with abdominal illness that needs a computed tomography examination
Criteria

Inclusion Criteria:

  • patients with abdominal illness that needs a computed tomography examination

Exclusion Criteria:


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00745641


Locations
Taiwan
NTUH
Taipei, Taiwan, 10002
Sponsors and Collaborators
National Taiwan University Hospital
Investigators
Principal Investigator: Zei-Shung Huang, MD, PhD NTUH

Responsible Party: Zei-Shung Huang, associate professor, Department of Internal Medicine, NTUH, National Taiwan University Hospital
ClinicalTrials.gov Identifier: NCT00745641     History of Changes
Other Study ID Numbers: 200807056R
First Posted: September 3, 2008    Key Record Dates
Last Update Posted: August 7, 2009
Last Verified: March 2009

Keywords provided by National Taiwan University Hospital:
radiation injury
computed tomography
reactive oxygen species
free radicals

Additional relevant MeSH terms:
Radiation Injuries
Wounds and Injuries