Abdominal Computed Tomography and the Blood Reactive Oxygen Species Level
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|ClinicalTrials.gov Identifier: NCT00745641|
Recruitment Status : Withdrawn (because of the presence of unexpected administrative barrier to interfere the collection of case)
First Posted : September 3, 2008
Last Update Posted : August 7, 2009
The clinically widely used X-ray computed tomography examination has a low-grade radiation effect and recently has attracted much attention concerning the possible adverse effects of radiation on human body [ref. 1-5]. The radiation is harmful to human tissues and cells mainly because it can interact with water (which makes up to 80% of cells) to generate reactive oxygen species (ROS), especially the formation of hydroxyl radicals. So far as we can reach, there is no report concerning the relation between X-ray computed tomography examination and the blood ROS level. Therefore, we wish to conduct this study to clarify if the routinely applied abdominal X-ray computed tomography examination may induce a higher level of ROS in the peripheral blood.
Study subjects will be patients who are admitted to our hospital because of abdominal diseases that need to receive abdominal X-ray computed tomography examination for diagnosis. In total, sixty cases will be enrolled for the study. The formal consent will be delivered and explained to the patients and families several hours before the performance of abdominal X-ray computed tomography. The formal consent will be retrieved and then the peripheral blood will be sampled just before the performance of computed tomography.ROS level in the sampled peripheral blood, before and after the performance of abdominal X-ray computed tomography, will be measured, compared, and analyzed. Totally 120 blood samples, including 60 samples just before and 60 samples 2 hours after the performance of computed tomography, will be collected from 60 study subjects within 5 months (August 10 ~ December 30, 2008). Reactive oxygen species（ROS）levels will be measured by a chemiluminescence (CL) analysing system (CLD-110, Tohoku Electronic Industrial, Sendai, Japan).
|Condition or disease|
|Study Type :||Observational|
|Estimated Enrollment :||60 participants|
|Observational Model:||Case Control|
|Official Title:||Effect of Abdominal X-ray Computed Tomography Examination on the Blood Reactive Oxygen Species Level|
|Study Start Date :||September 2008|
|Estimated Primary Completion Date :||December 2008|
|Estimated Study Completion Date :||December 2008|
Sixty patients with abdominal illness and scheduled abdominal X-ray computed tomography examination will be included.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00745641
|Taipei, Taiwan, 10002|
|Principal Investigator:||Zei-Shung Huang, MD, PhD||NTUH|