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Auditory Evoked Potentials and Experimental Pain

This study has been completed.
Information provided by:
Odense University Hospital Identifier:
First received: September 2, 2008
Last updated: NA
Last verified: September 2008
History: No changes posted
Monitoring of auditory evoked potentials (AEP) in patients during general anaesthesia is commonly used to ensure a sufficient hypnotic level during surgery. The amplitude of AEP (AEPa) has in clinical settings been found to correlate to pain. The aim of the study was to test, if AEPa could detect increasing experimental pain stimulations in healthy volunteers. Electric nerve stimulation, cold and heat pain were used as pain models.


Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: The Amplitude of Auditory Evoked Potentials and the Intensity of Experimental Pain Stimulation in Healthy Volunteers

Further study details as provided by Odense University Hospital:

Primary Outcome Measures:
  • VAS and amplitude of AEP [ Time Frame: before, during and after experimental pain ]

Secondary Outcome Measures:
  • reproducibility [ Time Frame: after an hour ]

Enrollment: 20
Study Start Date: October 2007
Study Completion Date: July 2008
Primary Completion Date: May 2008 (Final data collection date for primary outcome measure)

Detailed Description:

During the AEP monitoring, healthy volunteers were exposed to experimental pain. At study day 1: Firstly, single electric nerve stimulation and repetitive electric nerve stimulations causing temporal pain summation. The stimulations were given at 50, 75 and 100% of the thresholds for pain tolerance and temporal pain summation. Secondly, the volunteers were exposed to cold pain by use of two different Cold Pressor Tests (CPT) with water temperatures at 8 and 1 Celsius. All measurements were repeated after an hour to test reproducibility.

At study day 2: Brief Thermal Stimulation were used with two different temperatures and duration.


Ages Eligible for Study:   20 Years to 40 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
healthy volunteers

Inclusion Criteria:

  • Healthy
  • Age 20 - 40 years old
  Contacts and Locations
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Please refer to this study by its identifier: NCT00745472

Sponsors and Collaborators
Odense University Hospital
Principal Investigator: Thomas P Enggaard, MD Odense University Hospital
  More Information

Responsible Party: Thomas P. Enggaard MD, PHD, Department of Anaesthesiology, Odense University Hospital, Denmark Identifier: NCT00745472     History of Changes
Other Study ID Numbers: 30071993
Study First Received: September 2, 2008
Last Updated: September 2, 2008

Keywords provided by Odense University Hospital:
experimental pain
healthy volunteers processed this record on August 18, 2017