Primary Outcome Measures:
- VAS and amplitude of AEP [ Time Frame: before, during and after experimental pain ] [ Designated as safety issue: No ]
Secondary Outcome Measures:
- reproducibility [ Time Frame: after an hour ] [ Designated as safety issue: No ]
During the AEP monitoring, healthy volunteers were exposed to experimental pain. At study day 1: Firstly, single electric nerve stimulation and repetitive electric nerve stimulations causing temporal pain summation. The stimulations were given at 50, 75 and 100% of the thresholds for pain tolerance and temporal pain summation. Secondly, the volunteers were exposed to cold pain by use of two different Cold Pressor Tests (CPT) with water temperatures at 8 and 1 Celsius. All measurements were repeated after an hour to test reproducibility.
At study day 2: Brief Thermal Stimulation were used with two different temperatures and duration.