The Effect of Infliximab on Sperm Quality
|ClinicalTrials.gov Identifier: NCT00745329|
Recruitment Status : Unknown
Verified September 2008 by Tel-Aviv Sourasky Medical Center.
Recruitment status was: Not yet recruiting
First Posted : September 3, 2008
Last Update Posted : September 3, 2008
Background: The treatment of inflammatory bowel diseases (IBD) is based mainly on 3 compounds: 1- 5 aminosalysilates . 2- immunomodulators (Azathioprines). 3- Biologic therapies (Infliximab, Adalimumab) . There are no established data in the literature whether these therapies effects sperm quality. Given that a large number of the patients are young men in the reproductive stage of their lives , It of importance to investigate these effect.
Aim: To investigate the effect of chronic treatment of any of the three therapy mentioned above, on sperm quality .
|Condition or disease||Intervention/treatment|
|Crohn's Disease Ulcerative Colitis||Other: sperm quality test|
|Study Type :||Observational|
|Estimated Enrollment :||100 participants|
|Observational Model:||Case Control|
|Official Title:||The Effect of Infliximab,Adalimumab, Azathioprines and 5-Aminosalicylate on Semen Quality in Men With Inflammatory Bowel Disease|
|Study Start Date :||October 2008|
Other: sperm quality test
All participants will undergo sequential sperm quality tests and blood tests