Effect of Tai Chi Chuan on Autonomic Nervous Modulation in Aged Subjects
Since Tai Chi Chuan (TCC) training has been shown to be beneficial to the cardiopulmonary function of the subject, TCC might have a beneficial effect on the pulmonary function, autonomic nervous modulation, lipid profile, and cytokines production in the aged subjects.
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Effect of Tai Chi Chuan on Autonomic Nervous Modulation, Blood Lipid and Cytokines Production in Aged Subjects|
- TCC training for 3 months can improve the pulmonary function, glucose availability and lipid profile, and increase the cytokines production and vagal modulation in aged subjects. [ Time Frame: 3 months ] [ Designated as safety issue: No ]
- Other effects of TCC observed [ Time Frame: 3 months ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples Without DNA
Blood sample obtained from each subject was withdrawn for the quantitative measurements of total cholesterol (TC), high-density lipoprotein--cholesterol (HDL-C), high-density lipoprotein--cholesterol (LDL-C), triglyceride (TG), fasting blood sugar (FBS), and uric acid (UA). The immunoenzymometric assays for the quantitative measurement of tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) in the serum were also performed on the blood sample from each subject.
|Study Start Date:||May 2002|
|Study Completion Date:||March 2004|
|Primary Completion Date:||May 2003 (Final data collection date for primary outcome measure)|
Subjects in this group received TCC training for 3 months
Procedure: Tai Chi Cuan
Tai Chi Cuan training for 3 months
Other Name: Yang's Tai Chi Cuan
Subjects in this group received no TCC training within 3 months
Tai Chi Chuan (TCC) is a traditional Oriental conditioning exercise or calisthenics that is believed by many people around the world to be good for the health. The frequently claimed reason for this merit of TCC is that it can improve the cardiopulmonary function and immunity of the subject who practice it continuously. TCC has been shown to delay the decline of aerobic power, improve the cardiopulmonary function, balance and strength of the subjects. One study has demonstrated that TCC could reduce tension, anxiety, and mood disturbance. However, few studies have examined the effect of TCC on the blood lipid profile and immunity of the TCC practitioners. Another study reported that 12-week programme of regular TCC exercise enhanced functional mobility, personal health expectations, and regulatory T cell function. It has also been shown that an appropriate combination of TCC exercise program with diabetic medication might improve both glucose metabolism and immunity in type 2 diabetic patients. Since TCC training has been shown to be beneficial to the cardiopulmonary function of the subject, TCC may also have an effect on the blood lipid profile and immunity of the subjects. We hypothesize that TCC might have a beneficial effect on the pulmonary function, autonomic nervous modulation, lipid profile, and cytokines production in the aged subjects. Thus, the aim of this study was to examine whether or not TCC have these effects in the aged subjects.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00745303
|Taipei Veterans General Hospital|
|Taipei, Taiwan, 112|
|Principal Investigator:||Cheng-Deng Kuo, MD,PhD||Taipei Veterans General Hospital, Taiwan|