Comment Period Extended to 3/23/2015 for Notice of Proposed Rulemaking (NPRM) for FDAAA 801 and NIH Draft Reporting Policy for NIH-Funded Trials

Use Of Capnography As Surrogate Measure Of PC02 In Medical Intensive Care Unit (ICU) Patients

This study has been terminated.
(Principal Investigator (central contact) has left the organization and requests the study be terminated)
Information provided by:
Lahey Clinic Identifier:
First received: August 29, 2008
Last updated: October 19, 2010
Last verified: October 2010

The purpose of this study is to evaluate the use of Capnography (Continuous recording of the carbon dioxide content of expired air)as an alternative test to measure PC02 levels in patients with asthma, chronic obstructive pulmonary (COPD,interstitial lung disease(ILD)or coronary disease who are at risk of intubation.

Condition Intervention
Chronic Obstructive Pulmonary Disease
Interstitial Lung Disease
Procedure: Capnography

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Use Of Capnography As Surrogate Measure Of PC02 In Medical ICU Patients

Resource links provided by NLM:

Further study details as provided by Lahey Clinic:

Primary Outcome Measures:
  • PCO2 level [ Time Frame: 6 months ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Time to intubation [ Time Frame: 6 months ] [ Designated as safety issue: No ]

Estimated Enrollment: 70
Study Start Date: November 2007
Study Completion Date: October 2010
Primary Completion Date: October 2010 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Medical Intensive care unit patients with asthma, COPD, ILD or coronary disease who are at risk of intubation
Procedure: Capnography
A technique for monitoring the concentration or partial pressure of CO2 levels in respiratory gases

Detailed Description:

This is a prospective study to evaluate the usefulness of capnography as a non-invasive, accurate method of measuring of PC02 levels in medical intensive care unit patients with asthma, COPD, ILD, or coronary disease who are at risk of intubation.


Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

MICU patients who are at risk of intubation and who have a history of asthma, COPD, ILD or coronary disease.


Inclusion Criteria:

  • Medical Intensive Care Patients
  • Not intubated
  • Age 18 or older
  • History of any one of the following: asthma, COPD, ILD, or coronary disease

Exclusion Criteria:

  • Sepsis
  • Life expectancy less than 1 month
  • Requiring BIPAP
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00744614

United States, Massachusetts
Lahey Clinic, Inc.
Burlington, Massachusetts, United States, 01805
Sponsors and Collaborators
Lahey Clinic
Principal Investigator: David R. Riker, M.D. Lahey Clinic, Inc.
  More Information

Responsible Party: David Riker, M.D., Lahey Clinic, Inc. Identifier: NCT00744614     History of Changes
Other Study ID Numbers: 2007-115
Study First Received: August 29, 2008
Last Updated: October 19, 2010
Health Authority: United States: Institutional Review Board

Keywords provided by Lahey Clinic:
Respiratory Rate
Arterial blood gas

Additional relevant MeSH terms:
Lung Diseases, Interstitial
Lung Diseases, Obstructive
Pulmonary Disease, Chronic Obstructive
Lung Diseases
Respiratory Tract Diseases processed this record on February 27, 2015