Try our beta test site
IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more...

Impulsivity, Neural Deficits and Cocaine Addiction

This study has been completed.
National Institute on Drug Abuse (NIDA)
Dallas VA Medical Center
Information provided by (Responsible Party):
Bryon H Adinoff, University of Texas Southwestern Medical Center Identifier:
First received: June 19, 2008
Last updated: December 31, 2012
Last verified: December 2012
The purpose of this study is to assess neurocognitive and associated neural regions/circuitry disruptions relevant to impulsive relapse in cocaine-addicted subjects, and the relationship of the cognitive and neural mechanisms of impulsivity/decision-making to relapse style.

Cocaine Dependence

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Impulsivity, Neural Deficits, and Relapse in Cocaine Addiction

Resource links provided by NLM:

Further study details as provided by Bryon H Adinoff, University of Texas Southwestern Medical Center:

Primary Outcome Measures:
  • Determine if the brain regions involved in inhibition and decision-making are altered in cocaine-addicted subjects compared to healthy controls. [ Time Frame: 2 weeks ]
  • In cocaine-addicted subjects, determine if neural deficits during disinhibition or decision-making are related to relapse following treatment. [ Time Frame: 6 months ]

Secondary Outcome Measures:
  • Assess the predictive validity of self-report measures of impulsive relapse. [ Time Frame: 6 months ]

Biospecimen Retention:   Samples With DNA
urine, blood, plasma, and erythrocytes

Enrollment: 90
Study Start Date: April 2007
Study Completion Date: September 2012
Primary Completion Date: March 2012 (Final data collection date for primary outcome measure)
Patients with Cocaine Addiction
Healthy Control Volunteers

Detailed Description:
This study is designed to explore putative differences in impulsive behaviors and decision making in cocaine-addicted and healthy control subjects using functional magnetic resonance imaging (fMRI), single photon emission tomography (SPECT), and neurocognitive tasks. We predict that cocaine-addicted subjects will demonstrate neurocognitive and neural alterations in measures of impulsivity and decision-making when compared to healthy controls. That is, cocaine-addicted subjects will show both decreased activation and decreased resting measures of regional cerebral blood flow (rCBF) of the brain structures associated with impulsivity and decision-making. Furthermore, neurocognitive and neural deficits associated with impulsivity and decision-making will be associated with each other and with measures indicative of an impulsive relapse and altered decision making.

Ages Eligible for Study:   21 Years to 55 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Patients will be recruited from residential treatment programs at the VA North Texas Health Care System, Nexus Recovery Inc., and Homeward Bound Inc. Healthy controls will be recruited from the Greater Dallas community.

Inclusion Criteria:

  • Cocaine-dependence (patient population) or no cocaine-dependence (control population).

Exclusion Criteria:

  • Other medical or psychiatric disorders that may effect neural functioning.
  • Medications that may effect neural functioning.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00744601

United States, Texas
UT Southwestern Medical Center at Dallas, Divison on Addictions
Dallas, Texas, United States, 75390-8564
Sponsors and Collaborators
University of Texas Southwestern Medical Center
National Institute on Drug Abuse (NIDA)
Dallas VA Medical Center
Principal Investigator: Bryon Adinoff, MD UT Southwestern Medical Center at Dallas
  More Information

Responsible Party: Bryon H Adinoff, Professor, University of Texas Southwestern Medical Center Identifier: NCT00744601     History of Changes
Other Study ID Numbers: DA023203
1R01DA023203-01 ( US NIH Grant/Contract Award Number )
Study First Received: June 19, 2008
Last Updated: December 31, 2012

Keywords provided by Bryon H Adinoff, University of Texas Southwestern Medical Center:
cocaine dependence
functional magnetic resonance imaging (fMRI)
single photon emission computed tomography (SPECT)

Additional relevant MeSH terms:
Cocaine-Related Disorders
Impulsive Behavior
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders
Anesthetics, Local
Central Nervous System Depressants
Physiological Effects of Drugs
Sensory System Agents
Peripheral Nervous System Agents
Vasoconstrictor Agents
Dopamine Uptake Inhibitors
Neurotransmitter Uptake Inhibitors
Membrane Transport Modulators
Molecular Mechanisms of Pharmacological Action
Dopamine Agents
Neurotransmitter Agents processed this record on May 25, 2017