microRNA Expression in Renal Cell Carcinoma
In this study, renal cell carcinoma (RCC) related miRNA and the target genes of related miRNA will be examined in order to investigate the role of miRNA in the formation of RCC and look for the biomarker of RCC.
Carcinoma, Renal Cell
|Study Design:||Observational Model: Case-Only
Time Perspective: Cross-Sectional
|Official Title:||microRNA Expression in Renal Cell Carcinoma|
The tumor tissues and tumor adjacent tissues will be collected when patients receive renal cell carcinoma resection.
The blood and urine will be collected before patients receive operation. And the blood and urine of some healthy volunteers will be collected as the control group.
|Study Start Date:||July 2008|
|Study Completion Date:||August 2011|
|Primary Completion Date:||August 2009 (Final data collection date for primary outcome measure)|
Due to the lack of specific indicators for the early diagnosis of RCC, the RCC patients often have distant metastasis when diagnosed and their five-year survival rate is much low. Therefore, the biological markers of RCC are needed for early detection, early treatment and improvement of the survival rate of RCC patients.
MiRNA and tumor are closely related. MiRNA can control the important cancer-related genes and participate in the tumor cell proliferation, apoptosis, invasion and angiogenesis.
In this study, RCC related miRNA and the target genes of related miRNA will be examined,and the relationship between RCC related miRNA and the RCC pathological types, TNM (tumor-nodes-metastasis) stages and prognosis will be analyzed. The purpose of this study is to investigate the role of miRNA in the formation of RCC and look for the biomarker of RCC.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00743054
|The 1st Affiliated Hospital, Sun Yet-sen University|
|GuangZhou, Guangdong, China, 510080|
|Principal Investigator:||Xueqing Yu, M.D. & Ph.D.||1st Affiliated Hospital, Sun Yat-Sen University|