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Discriminating Ability of the Cirrus High Definition (HD) Optical Coherence Tomography (OCT) for Glaucoma

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified September 2008 by Yonsei University.
Recruitment status was:  Recruiting
Information provided by:
Yonsei University Identifier:
First received: August 26, 2008
Last updated: September 22, 2008
Last verified: September 2008
The Cirrus HD OCT, a new spectral domain optical coherence tomography, has better resolution than the previous OCT. Reproducibility and discriminating ability of the Cirrus HD OCT for glaucoma detection will be studied.


Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Discriminating Ability of the Cirrus HD OCT for Glaucoma

Resource links provided by NLM:

Further study details as provided by Yonsei University:

Primary Outcome Measures:
  • Retinal nerve fiber layer thickness [ Time Frame: when the OCT images are taking ]

Secondary Outcome Measures:
  • Red-free fundus photo [ Time Frame: when the OCT images are taking ]
  • Visual field [ Time Frame: when the OCT images are taking ]
  • Intraocular pressure [ Time Frame: when the OCT images are taking ]

Estimated Enrollment: 200
Study Start Date: September 2008
Estimated Study Completion Date: December 2008
Estimated Primary Completion Date: October 2008 (Final data collection date for primary outcome measure)
Normal controls

Detailed Description:
The Cirrus HD OCT is a newly developed imaging device of the spectral domain optical coherence tomography. Even though its resolution and speed are much better than the previous OCT, its reproducibility and diagnostic power for detecting the glaucomatous defect of retinal nerve fiber layer (RNFL) have not known yet. In the present study, we will review the data of RNFL thickness measurement using the Cirrus HD OCT. After assessing the inter-test variability, the discriminating ability of the Cirrus HD OCT for glaucoma diagnosis will be determined by the ROC curves.

Ages Eligible for Study:   18 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Glaucoma patients and normal controls

Inclusion Criteria:

  • Cooperative patients
  • Repeated OCT data

Exclusion Criteria:

  • Intraocular surgeries history
  • DM
  • High refractive error ( < -4.00 diopters, or > + 4.00 diopters)
  • Media opacity
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00742378

Contact: Gong Je Seong, MD, PhD 82-2-2019-3441

Korea, Republic of
Gong Je Seong Recruiting
Seoul, Korea, Republic of, 135-720
Contact: Gong Je Seong, MD, PhD    82-2-2019-3441   
Principal Investigator: Gong Je Seong, MD, PhD         
Sponsors and Collaborators
Yonsei University
Principal Investigator: Gong Je Seong, MD, PhD Yonsei University
  More Information

Responsible Party: Gong Je Seong, Yonsei University College of Medicine Identifier: NCT00742378     History of Changes
Other Study ID Numbers: 3-2008-0076-Reproducibility
Study First Received: August 26, 2008
Last Updated: September 22, 2008

Keywords provided by Yonsei University:
Retinal nerve fiber layer
Cirrus OCT

Additional relevant MeSH terms:
Ocular Hypertension
Eye Diseases processed this record on May 25, 2017