A Study of the Association Between Tobacco Smoking and Bipolar Affective Disorder
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ClinicalTrials.gov Identifier: NCT00741299
Recruitment Status :
First Posted : August 26, 2008
Last Update Posted : July 26, 2012
Tirat Carmel Mental Health Center
Information provided by (Responsible Party):
Anatoly Dr. Kreinin, Tirat Carmel Mental Health Center
The purpose of this study is to examine whether tobacco smoking is associated with bipolar affective disorder (severity of depressive and manic symptoms, presence of psychotic symptoms, history of a suicide attempts and other clinical features.)
Condition or disease
An association exists between smoking and schizophrenia, independent of other factors and related to psychotic symptomatology. Only a few small descriptive studies have examined the prevalence and correlates of tobacco use among bipolar patients with conflicting results. Patients who smoke score higher on rating scales for psychotic symptoms than their non-smoking peers. While the association of smoking with psychotic symptomatology in schizophrenia is established, such association according to bipolar affective disorder has been reported in a few studies and remains unclear. Also a few studies reported about association of smoking with depressive and manic symptoms, and with suicidal behavior in bipolar patients. Thus further investigation of these issues is warranted.
Relationship between smoking and other factors including: bipolar subtype, current and past clinical status, illness severity,history of a suicide attempts, age of bipolar onset, gender, education, social class, economic status. [ Time Frame: One interview session ]
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Ages Eligible for Study:
18 Years to 65 Years (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
The sample will consist of all patients ascertained in database of Tirat Carmel Mental Health Center and Psychiatric Outpatients Clinic, Rambam Medical Center
Age 18-65 male or female
DSM -IV criteria for bipolar I affective disorder
Ability and willingness to sign informed consent for participation in the study
Unwillingness or inability to participate in the study