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A Study of the Association Between Tobacco Smoking and Bipolar Affective Disorder

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00741299
First Posted: August 26, 2008
Last Update Posted: July 26, 2012
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Anatoly Dr. Kreinin, Tirat Carmel Mental Health Center
  Purpose
The purpose of this study is to examine whether tobacco smoking is associated with bipolar affective disorder (severity of depressive and manic symptoms, presence of psychotic symptoms, history of a suicide attempts and other clinical features.)

Condition
Bipolar Disorder

Study Type: Observational
Study Design: Time Perspective: Retrospective
Official Title: Association Between Tobacco Smoking and Bipolar Affective Disorder.Clinico-epidemiological, Cross-sectional, Retrospective Study.

Resource links provided by NLM:


Further study details as provided by Anatoly Dr. Kreinin, Tirat Carmel Mental Health Center:

Primary Outcome Measures:
  • Relationship between smoking and other factors including: bipolar subtype, current and past clinical status, illness severity,history of a suicide attempts, age of bipolar onset, gender, education, social class, economic status. [ Time Frame: One interview session ]

Enrollment: 100
Study Start Date: August 2007
Study Completion Date: September 2009
Primary Completion Date: July 2009 (Final data collection date for primary outcome measure)
Detailed Description:
An association exists between smoking and schizophrenia, independent of other factors and related to psychotic symptomatology. Only a few small descriptive studies have examined the prevalence and correlates of tobacco use among bipolar patients with conflicting results. Patients who smoke score higher on rating scales for psychotic symptoms than their non-smoking peers. While the association of smoking with psychotic symptomatology in schizophrenia is established, such association according to bipolar affective disorder has been reported in a few studies and remains unclear. Also a few studies reported about association of smoking with depressive and manic symptoms, and with suicidal behavior in bipolar patients. Thus further investigation of these issues is warranted.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
The sample will consist of all patients ascertained in database of Tirat Carmel Mental Health Center and Psychiatric Outpatients Clinic, Rambam Medical Center
Criteria

Inclusion Criteria:

  • Age 18-65 male or female
  • DSM -IV criteria for bipolar I affective disorder
  • Ability and willingness to sign informed consent for participation in the study

Exclusion Criteria:

  • Unwillingness or inability to participate in the study
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00741299


Locations
Israel
Tirat Carmel Mental Health Center
Tirat HaCarmel, Israel, 30200
Sponsors and Collaborators
Tirat Carmel Mental Health Center
Investigators
Principal Investigator: Anatoly Kreinin, MD, PHD B. Rappaport Faculty of Medicine, Technion, Haifa
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Anatoly Dr. Kreinin, Director of psychiatric department, Tirat Carmel Mental Health Center
ClinicalTrials.gov Identifier: NCT00741299     History of Changes
Other Study ID Numbers: GKN2007
First Submitted: August 25, 2008
First Posted: August 26, 2008
Last Update Posted: July 26, 2012
Last Verified: July 2012

Keywords provided by Anatoly Dr. Kreinin, Tirat Carmel Mental Health Center:
bipolar affective disorder, Smoking

Additional relevant MeSH terms:
Disease
Bipolar Disorder
Mood Disorders
Genetic Diseases, X-Linked
Pathologic Processes
Bipolar and Related Disorders
Mental Disorders
Genetic Diseases, Inborn