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Acute Effects of Smoking on Airway Dendritic Cells

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT00740896
Recruitment Status : Completed
First Posted : August 25, 2008
Last Update Posted : April 8, 2009
Sponsor:
Collaborator:
Information provided by:

Study Description
Brief Summary:
Airway dendritic cells control pulmonary immune responses to inhaled particles. It is the aim of the present study to investigate the acute effects of smoking on the number and surface molecule expression of human airway dendritic cells.

Condition or disease Intervention/treatment
Tobacco Use Disorder Behavioral: Smoking

Study Design

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 16 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Acute Effects of Smoking on Airway Dendritic Cells
Study Start Date : June 2008
Primary Completion Date : November 2008
Study Completion Date : December 2008

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Smoking
U.S. FDA Resources

Arms and Interventions

Arm Intervention/treatment
Active Comparator: 1
Participants smoke 8 cigarettes in 4 hours.
Behavioral: Smoking
Active Comparator: Participants smoke 8 cigarettes in 4 hours.
Sham Comparator: 2
Participants are not allowed to smoke for 4 hours.
Behavioral: Smoking
Sham Comparator: Participants are not allowed to smoke for 4 hours.


Outcome Measures

Primary Outcome Measures :
  1. Total number of dendritic cells in bronchoalveolar lavage fluid [ Time Frame: June - September 2008 ]

Secondary Outcome Measures :
  1. Surface molecule expression on dendritic cells in bronchoalveolar lavage fluid [ Time Frame: June - September 2008 ]

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Active smoking (at least 10 cigarettes per day)
  • Age > 18 years

Exclusion Criteria:

  • Any chronic diseases
  • Any regular medication
  • Any signs or symptoms of an acute infection
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00740896


Locations
Germany
University of Rostock
Rostock, Germany, 18057
Sponsors and Collaborators
University of Rostock
German Research Foundation
Investigators
Study Chair: Johann C. Virchow, Professor, MD, FRCP, FCCP University of Rostock
More Information

Publications:
Responsible Party: PD Dr. med. Marek Lommatzsch, University of Rostock
ClinicalTrials.gov Identifier: NCT00740896     History of Changes
Other Study ID Numbers: LO-2222
First Posted: August 25, 2008    Key Record Dates
Last Update Posted: April 8, 2009
Last Verified: April 2009

Keywords provided by University of Rostock:
Cigarette Smoking
Airway dendritic cells

Additional relevant MeSH terms:
Tobacco Use Disorder
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders