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Acute Effects of Smoking on Airway Dendritic Cells

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00740896
First Posted: August 25, 2008
Last Update Posted: April 8, 2009
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
German Research Foundation
Information provided by:
University of Rostock
  Purpose
Airway dendritic cells control pulmonary immune responses to inhaled particles. It is the aim of the present study to investigate the acute effects of smoking on the number and surface molecule expression of human airway dendritic cells.

Condition Intervention
Tobacco Use Disorder Behavioral: Smoking

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Acute Effects of Smoking on Airway Dendritic Cells

Resource links provided by NLM:


Further study details as provided by University of Rostock:

Primary Outcome Measures:
  • Total number of dendritic cells in bronchoalveolar lavage fluid [ Time Frame: June - September 2008 ]

Secondary Outcome Measures:
  • Surface molecule expression on dendritic cells in bronchoalveolar lavage fluid [ Time Frame: June - September 2008 ]

Enrollment: 16
Study Start Date: June 2008
Study Completion Date: December 2008
Primary Completion Date: November 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: 1
Participants smoke 8 cigarettes in 4 hours.
Behavioral: Smoking
Active Comparator: Participants smoke 8 cigarettes in 4 hours.
Sham Comparator: 2
Participants are not allowed to smoke for 4 hours.
Behavioral: Smoking
Sham Comparator: Participants are not allowed to smoke for 4 hours.

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Active smoking (at least 10 cigarettes per day)
  • Age > 18 years

Exclusion Criteria:

  • Any chronic diseases
  • Any regular medication
  • Any signs or symptoms of an acute infection
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00740896


Locations
Germany
University of Rostock
Rostock, Germany, 18057
Sponsors and Collaborators
University of Rostock
German Research Foundation
Investigators
Study Chair: Johann C. Virchow, Professor, MD, FRCP, FCCP University of Rostock
  More Information

Publications:
Responsible Party: PD Dr. med. Marek Lommatzsch, University of Rostock
ClinicalTrials.gov Identifier: NCT00740896     History of Changes
Other Study ID Numbers: LO-2222
First Submitted: August 22, 2008
First Posted: August 25, 2008
Last Update Posted: April 8, 2009
Last Verified: April 2009

Keywords provided by University of Rostock:
Cigarette Smoking
Airway dendritic cells

Additional relevant MeSH terms:
Tobacco Use Disorder
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders