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Effects of Transcranial Magnetic Stimulation to the Cerebellum on Cognition

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ClinicalTrials.gov Identifier: NCT00740701
Recruitment Status : Enrolling by invitation
First Posted : August 25, 2008
Last Update Posted : February 2, 2018
Sponsor:
Collaborators:
National Institute of Mental Health (NIMH)
National Institute on Aging (NIA)
Information provided by (Responsible Party):
Johns Hopkins University

Brief Summary:
Functional neuroimaging studies have shown that the cerebellum is active during cognitive performance. The investigators hypothesize that stimulation of the cerebellum with transcranial magnetic stimulation will produce brief changes in performance of the task, suggesting that cerebellar activation is necessary for normal cognitive function.

Condition or disease Intervention/treatment Phase
Cognitive Performance Device: Cerebellar transcranial magnetic stimulation Not Applicable

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 188 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single (Participant)
Primary Purpose: Basic Science
Official Title: fMRI and TMS Analysis of Cerebellar Cognitive Function
Study Start Date : April 2000
Estimated Primary Completion Date : February 28, 2018
Estimated Study Completion Date : February 28, 2018

Arm Intervention/treatment
Sham Comparator: Sham TMS
A Sham TMS coil, designed to elicit sham cerebellar transcranial magnetic stimulation, is used to administer sham TMS pulses after letters are presented.
Device: Cerebellar transcranial magnetic stimulation
single pulse TMS or repetitive TMS at 1 Hz frequency
Experimental: TMS
A genuine TMS coil is used to administer cerebellar transcranial magnetic stimulation pulses after letter presentation.
Device: Cerebellar transcranial magnetic stimulation
single pulse TMS or repetitive TMS at 1 Hz frequency



Primary Outcome Measures :
  1. Behavioral performance (accuracy, or rate of conditioned responses) [ Time Frame: during computerized task performance (2 hours) ]

Secondary Outcome Measures :
  1. Reaction time [ Time Frame: during performance of computerized task (2 hours) ]


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Ages Eligible for Study:   19 Years to 30 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • 19-30 years of age
  • Informed consent

Exclusion Criteria:

  • History of seizure or a family history of epilepsy
  • History of stroke
  • Presence of metal anywhere in the head except the mouth
  • Presence of cardiac pacemakers
  • Presence of cochlear implants
  • Presence of implanted medication pump
  • History of heart disease
  • Presence of intracardiac lines
  • Increased intracranial pressure, such as after infarctions or trauma
  • Children, or outside of age range
  • Pregnancy
  • Currently taking tricyclic anti-depressants or neuroleptic medication
  • History of head trauma
  • History of respiratory disease

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00740701


Locations
United States, Maryland
Kennedy Krieger Institute
Baltimore, Maryland, United States, 21205
Sponsors and Collaborators
Johns Hopkins University
National Institute of Mental Health (NIMH)
National Institute on Aging (NIA)
Investigators
Principal Investigator: John E Desmond, Ph.D. Johns Hopkins University

Responsible Party: Johns Hopkins University
ClinicalTrials.gov Identifier: NCT00740701     History of Changes
Other Study ID Numbers: NA_00044841
R01MH060234 ( U.S. NIH Grant/Contract )
R01AG021501 ( U.S. NIH Grant/Contract )
First Posted: August 25, 2008    Key Record Dates
Last Update Posted: February 2, 2018
Last Verified: January 2018

Keywords provided by Johns Hopkins University:
TMS
fMRI
verbal working memory
classical conditioning
eyeblink
classical eyeblink conditioning
Healthy subjects
Memory