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Effects of Transcranial Magnetic Stimulation to the Cerebellum on Cognition

This study is enrolling participants by invitation only.
National Institute of Mental Health (NIMH)
National Institute on Aging (NIA)
Information provided by (Responsible Party):
John E. Desmond, Johns Hopkins University Identifier:
First received: August 22, 2008
Last updated: March 7, 2017
Last verified: March 2017
Functional neuroimaging studies have shown that the cerebellum is active during cognitive performance. The investigators hypothesize that stimulation of the cerebellum with transcranial magnetic stimulation will produce brief changes in performance of the task, suggesting that cerebellar activation is necessary for normal cognitive function.

Condition Intervention
Cognitive Performance
Device: Cerebellar transcranial magnetic stimulation

Study Type: Interventional
Study Design: Intervention Model: Crossover Assignment
Masking: Participant
Primary Purpose: Basic Science
Official Title: fMRI and TMS Analysis of Cerebellar Cognitive Function

Further study details as provided by John E. Desmond, Johns Hopkins University:

Primary Outcome Measures:
  • Behavioral performance (accuracy, or rate of conditioned responses) [ Time Frame: during computerized task performance (2 hours) ]

Secondary Outcome Measures:
  • Reaction time [ Time Frame: during performance of computerized task (2 hours) ]

Estimated Enrollment: 188
Study Start Date: April 2000
Estimated Study Completion Date: July 2017
Estimated Primary Completion Date: July 2017 (Final data collection date for primary outcome measure)
Intervention Details:
    Device: Cerebellar transcranial magnetic stimulation
    single pulse TMS or repetitive TMS at 1 Hz frequency

Ages Eligible for Study:   19 Years to 30 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • 19-30 years of age
  • Informed consent

Exclusion Criteria:

  • History of seizure or a family history of epilepsy
  • History of stroke
  • Presence of metal anywhere in the head except the mouth
  • Presence of cardiac pacemakers
  • Presence of cochlear implants
  • Presence of implanted medication pump
  • History of heart disease
  • Presence of intracardiac lines
  • Increased intracranial pressure, such as after infarctions or trauma
  • Children, or outside of age range
  • Pregnancy
  • Currently taking tricyclic anti-depressants or neuroleptic medication
  • History of head trauma
  • History of respiratory disease
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00740701

United States, Maryland
Kennedy Krieger Institute
Baltimore, Maryland, United States, 21205
Sponsors and Collaborators
John E. Desmond
National Institute of Mental Health (NIMH)
National Institute on Aging (NIA)
Principal Investigator: John E Desmond, Ph.D. Johns Hopkins University
  More Information

Responsible Party: John E. Desmond, Professor of Neurology, Johns Hopkins University Identifier: NCT00740701     History of Changes
Other Study ID Numbers: G000078
R01MH060234 ( US NIH Grant/Contract Award Number )
R01AG021501 ( US NIH Grant/Contract Award Number )
Study First Received: August 22, 2008
Last Updated: March 7, 2017

Keywords provided by John E. Desmond, Johns Hopkins University:
verbal working memory
classical conditioning
classical eyeblink conditioning
Healthy subjects
Memory processed this record on May 25, 2017