Factors That Affect the Development of COPD Symptoms
|ClinicalTrials.gov Identifier: NCT00740337|
Recruitment Status : Unknown
Verified September 2012 by Washington University School of Medicine.
Recruitment status was: Enrolling by invitation
First Posted : August 22, 2008
Last Update Posted : September 17, 2012
|Condition or disease|
|Pulmonary Disease, Chronic Obstructive|
COPD is a chronic lung disease in which the lungs' airways and balloon-like air sacs, called alveoli, are damaged, lose their shape, and become floppy. As a result, they cannot fully inflate to allow the maximum amount of air through. COPD is usually the result of many years of cigarette smoking. Breathing in other kinds of lung irritants, such as pollution, dust, or chemicals, over a long period of time may also cause or contribute to COPD. Some people with COPD have an excess of mucus in their lungs, possibly caused by an overactive immune response, which can lead to coughing and shortness of breath. Although cigarette smoking seems to make this symptom worse, researchers are not sure why it occurs in some people and not others. This study will examine and compare blood and lung tissue samples from smokers and nonsmokers with and without COPD to determine what physiological differences, environmental factors, genes, and biomarkers contribute to the development of and symptoms associated with COPD.
Before their scheduled lung resection surgery, participants in this study will attend one study visit. It will last approximately 1 to 2 hours and will consist of answering questions about medical history, filling out health questionnaires, and providing a blood sample. After the surgery, study researchers will take the lung tissue that was removed and examine it in a laboratory. Participants will be contacted by study staff if, when examining the lung tissue, researchers discover that a participant has a medical disorder that current treatment can stop or improve. Also, participants will be contacted at the end of the study to answer brief questions about their health.
|Study Type :||Observational|
|Actual Enrollment :||82 participants|
|Official Title:||Specialized Center of Clinically Oriented Research: Alveolar and Airway Mechanisms of COPD. Airway Determinants: Innate Immune Signaling (Project 4)|
|Study Start Date :||October 2007|
|Estimated Primary Completion Date :||August 2013|
|Estimated Study Completion Date :||August 2013|
Participants in this group will be people who have COPD and plan to undergo lung resection surgery at Barnes-Jewish Hospital (BJH).
Participants in this group will be people who do not have COPD and plan to undergo lung resection surgery at BJH.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00740337
|United States, Missouri|
|Washington University School of Medicine|
|St. Louis, Missouri, United States, 63110|
|Principal Investigator:||Michael J. Holtzman, MD||Pulmonary and Critical Care, Washington University School of Medicine|