Reciprocal Influence of Sex Steroid Environment and Adipocyte Function in Men
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Ages Eligible for Study:
18 Years to 40 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Informed consent obtained.
Age 18 - 40
weight < 120 kg
Primary hypogonadism or secondary hypogonadism due to genetic causes (Kallman syndrome etc.), tumors, infiltrative diseases, infections, pituitary apoplexy, trauma, critical illness, chronic systemic illness or intentional.
Treatment with insulin, corticoids, opiates (on a daily basis), androgen- or estrogen analogs or CYP2A6 substrates (Dexmedetomidine, Ifosfamide, Methoxsalen, Miconazole, Tranylcypromine).
Impaired renal function defined as serum-creatine > 1.5 mg/dL
Impaired liver function, defined as ALAT > 2.5 times upper limit of normal
Clinically significant active cardiovascular disease including history of myocardial infarction within the past 6 months and/or heart failure (NYHA class III or IV) at the discretion of the investigator
Cancer or any clinically significant disease or disorder, which in the investigator's opinion could interfere with the results of the trial
Palpable prostate nodule or induration, PSA > 3 ng/mL, prostatism, untreated sleep apnee syndrome, erythrocytosis (hematocrit > 50%) or hyperviscosity.
Known or suspected abuse of alcohol or narcotics
Mental incapacity, unwillingness, or language barrier precluding adequate understanding or cooperation.