The Polymerase Chain Reaction (PCR) Analysis of Nasal Polyps for Fungal DNA
Recruitment status was: Recruiting
|Study Design:||Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Diagnostic
|Official Title:||PCR Analysis of Nasal Polyps for Fungal DNA|
- Quality of life (QOL) instruments: Medical Outcomes Study 36-Item Short Form (SF-36) and the Sino-Nasal Outcomes Study- 20 questions (SNOT-20). [ Time Frame: During the course of outpatient visit ] [ Designated as safety issue: No ]
|Study Start Date:||June 2006|
|Estimated Study Completion Date:||May 2015|
|Estimated Primary Completion Date:||May 2015 (Final data collection date for primary outcome measure)|
Patients with sinusitis compared to patients without.
To find out if any specific type of fungus or mold is correlated with chronic sinus disease. The study will add new information about the different types of fungus and mold found in the human nose.
Procedure: Nasal swab under endoscopic guidance
After the application of pontocaine and neosynephrine spray, the following will be done:
The samples will be refrigerated and analyzed using PCR to detect and speciate fungus.
The objective of this study is to determine whether the amount or type of fungal DNA present in the nose and home environment can be correlated with the outcomes of the following quality of life (QOL) instruments: Medical Outcomes Study 36-item Short Form (SF-36) and the Sino-Nasal Outcomes Study - 20 Questions (SNOT-20).
The study design involves case control Polymerase Chain reaction (PCR) analysis of nasal mucosal swabs, saliva swabs, blood serum, and home vacuum cleaner bags in patients with sinusitis and normal controls.
The hypothesis is that the quantity and type of fungal DNA present in the nose and home environment are directly correlated with quality of life. Our research aims to both quantify the amount of fungi present in the nasal mucosa as well as to measure the severity of the patient's chronic rhinosinusitis (CRS) as a function of SNOT-20 and SF-36 outcomes questionnaires. We hypothesize that the amount and type of fungi present in the nose and home environment will correlate with the severity of the patients' symptoms of CRS.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00739921
|United States, California|
|University of California, San Francisco, Dept of Otolaryngology-HNS|
|San Francisco, California, United States, 94143|
|Principal Investigator:||Andrew Murr, MD||University of California, San Francisco|