Effects of Sea Buckthorn Oil on Dry Eye (DESB)
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ClinicalTrials.gov Identifier: NCT00739713 |
Recruitment Status :
Completed
First Posted : August 22, 2008
Last Update Posted : March 20, 2018
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Dry Eye Syndromes | Dietary Supplement: Sea buckthorn (Hippophaë rhamnoides) oil Dietary Supplement: Placebo comparison | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 100 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor) |
Primary Purpose: | Treatment |
Official Title: | Effects of Sea Buckthorn Oil on Dry Eye |
Actual Study Start Date : | September 2008 |
Actual Primary Completion Date : | March 2009 |
Actual Study Completion Date : | March 2009 |

Arm | Intervention/treatment |
---|---|
Experimental: SB
Sea buckthorn oil group
|
Dietary Supplement: Sea buckthorn (Hippophaë rhamnoides) oil
Dosage 2 g/d, frequency twice/d, duration 3 months |
Placebo Comparator: PL
Placebo group
|
Dietary Supplement: Placebo comparison
Placebo comparison, dosage 2 g/d, frequency twice/d, duration 3 months |
- Symptom severity: symptom questionnaires and clinical dry eye tests [ Time Frame: 3 months intervention + 1 month after the intervention ]
- Tear film lipid profile, tear cytokines, inflammation mediators in blood [ Time Frame: 3 months intervention + 1 month after the intervention ]

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Ages Eligible for Study: | 20 Years to 75 Years (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- Dry eye symptoms
Exclusion Criteria:
- Severe illness
- Anticholinergic drugs
- Smoking

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00739713
Finland | |
University of Turku | |
Turku, Finland, 20014 |
Study Director: | Heikki P Kallio, Professor | University of Turku |
Other Publications:
Responsible Party: | Matti Viitanen/ Professor, University of Turku |
ClinicalTrials.gov Identifier: | NCT00739713 |
Other Study ID Numbers: |
DESB |
First Posted: | August 22, 2008 Key Record Dates |
Last Update Posted: | March 20, 2018 |
Last Verified: | March 2017 |
dry eye sea buckthorn Hippophaë |
Dry Eye Syndromes Keratoconjunctivitis Sicca Lacrimal Apparatus Diseases Eye Diseases Keratoconjunctivitis |
Conjunctivitis Conjunctival Diseases Keratitis Corneal Diseases |