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Effect of Systematic Medication Review in Elderly Patients Admitted to an Orthopedic Department

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00738816
Recruitment Status : Completed
First Posted : August 21, 2008
Last Update Posted : December 14, 2010
Information provided by:
University of Aarhus

Brief Summary:

Elderly patients have a higher risk of experiencing adverse drug events due to an age related increase in morbidity and medication use. Inappropriate or wrong medication use among elderly patients acutely admitted to hospitals is assumed to result in earlier contact to general practitioner, emergency departments and re-admissions if not corrected during hospital admission. It is therefore our hypothesis that a systematic medication review conducted by pharmacists and physicians specialized in pharmacology will increase time to first unscheduled physician contact (general practitioner, emergency departments, ambulatory care and re-admissions) after discharge from hospital from an average of 21days to 25 days. Further, the following secondary outcome parameters will be measured at discharge and within 3-month follow-up:

  • length of in-hospital stay
  • number of contacts to general practitioner 30 days after discharge, that resulted in medication changes
  • number of re-admissions at 3-month
  • number of death at 3-month
  • number of contact to primary health care at 3-month
  • patients self-experienced quality of health(EQ-5D) 3-month

Condition or disease Intervention/treatment Phase
Elderly Other: Systematic medication review and advisory notes Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 108 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Prevention
Official Title: The Effect of Systematic Medication Review in Elderly Patients Admitted to an Orthopedic Department.
Study Start Date : April 2009
Actual Primary Completion Date : February 2010
Actual Study Completion Date : April 2010

Resource links provided by the National Library of Medicine

Arm Intervention/treatment
Systematic medication review
Other: Systematic medication review and advisory notes
Within 24 hours of admission a pharmacist retrieve medication histories from patients included in the intervention group. Medication histories will be obtained from - medical records, medication charts, patients electronical medication profile, interview with patients and if necessary contact to the patients general practitioner. The obtained medication history will be discussed with a physician specialized in pharmacology and an advisory note with suggested changes to the patients medication is added to the medical record. The orthopedic physicians are not obliged to follow the suggested changes

Primary Outcome Measures :
  1. Time to first unscheduled physician contact(general practitioner,emergency department, ambulatory care or re-admission to hospital) after discharge from the Orthopaedic Department [ Time Frame: January 2010 ]

Secondary Outcome Measures :
  1. Admission time [ Time Frame: October 2009 ]

Information from the National Library of Medicine

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Ages Eligible for Study:   65 Years and older   (Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • age 65 years or older
  • expected admission time of more than 24 hours
  • acute admission

Exclusion Criteria:

  • Psychotic patients
  • Moribund patients
  • Suicidal patients

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00738816

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Regional hospital, Randers
Randers, Central Denmark Region, Denmark, 8900
Sponsors and Collaborators
Aarhus University Hospital
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Principal Investigator: Nielsen Lars Peter, Assoc. Prof. Aarhus University Hospital, Denmark
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Responsible Party: Marianne Lisby, Aarhus University Hospital Identifier: NCT00738816    
Other Study ID Numbers: Klinfarm
First Posted: August 21, 2008    Key Record Dates
Last Update Posted: December 14, 2010
Last Verified: December 2010
Keywords provided by University of Aarhus:
Medication review