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Effects of Ambient Air Pollution Exposure in Patients With Stable Angina Pectoris During Normal Daily Activities

This study has been terminated.
(Study performed in alternative location (Beijing China))
Imperial College London
Information provided by (Responsible Party):
Jeremy Langrish, University of Edinburgh Identifier:
First received: August 19, 2008
Last updated: December 1, 2014
Last verified: December 2014
The purpose of this study is to identify whether exposure to ambient levels of air pollution during normal daily activities has a functional impact on patients with coronary heart disease

Angina Pectoris
Coronary Heart Disease

Study Type: Observational
Study Design: Observational Model: Case-Crossover
Time Perspective: Prospective
Official Title: Effects of Ambient Air Pollution Exposure in Patients With Stable Angina Pectoris During Normal Daily Activities

Resource links provided by NLM:

Further study details as provided by Jeremy Langrish, University of Edinburgh:

Primary Outcome Measures:
  • Symptoms of angina pectoris - assessed by symptom diary and reliever medication usage [ Time Frame: Throughout study period ]

Secondary Outcome Measures:
  • Myocardial ischaemic burden - assessed using 12-lead continuous Holter ECG monitoring [ Time Frame: Throughout study period ]
  • Time to 1mm ST segment depression during standard BRUCE exercise stress testing [ Time Frame: At the end of the study period ]
  • Total exercise capacity - measured using GPS tracking of activity completed [ Time Frame: Throughout study period ]
  • Exercise capacity - determined by standard BRUCE exercise stress testing [ Time Frame: Immediately after study period ]
  • Ambulatory blood pressure [ Time Frame: Throughout study period ]
  • Biochemical evidence of myocardial ischaemia - highly sensitive troponin, ischaemically modified albumin and fatty acid binding protein [ Time Frame: Before and after study period ]

Biospecimen Retention:   Samples Without DNA
Plasma samples Serum samples

Enrollment: 1
Study Start Date: August 2008
Study Completion Date: August 2013
Primary Completion Date: August 2013 (Final data collection date for primary outcome measure)
Patients with stable angina pectoris and documented coronary heart disease recruited in Edinburgh
Patients with stable angina pectoris and documented coronary heart disease recruited in London

Detailed Description:
Exposure to air pollution has been shown in epidemiological studies to be closely linked to cardiovascular morbidity and mortality. The exact components of air pollution that underlie the cardiovascular effects are not yet known, but combustion-derived particulate matter is suspected to be the major cause. In controlled exposure studies, we have recently demonstrated that exposure to diesel exhaust causes increased myocardial ischaemia with exercise in patients with asymptomatic coronary artery disease. The mechanism behind this effect is not yet understood, but we have shown that diesel exhaust exposure causes an acute impairment of two important and highly relevant aspects of vascular tone: vasomotor tone and endogenous fibrinolysis. In this study we propose to investigate the effects of exposure to ambient levels of air pollution on patients with stable, symptomatic angina pectoris, during their daily lives.

Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients with stable angina pectoris and documented coronary artery disease

Inclusion Criteria:

  • Documented coronary artery disease
  • Symptoms of stable angina pectoris
  • Positive BRUCE exercise stress test between 3 and 13 minutes

Exclusion Criteria:

  • History of arrhythmia
  • Severe 3 vessel coronary disease or left main stem stenosis that has not been revascularised
  • Resting conduction abnormality
  • Digoxin therapy
  • Uncontrolled hypertension
  • Renal or hepatic failure
  • Unstable symptoms or acute coronary syndrome within 3 months
  Contacts and Locations
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Please refer to this study by its identifier: NCT00738491

United Kingdom
University of Edinburgh
Edinburgh, Midlothian, United Kingdom, EH16 4SB
Imperial College
London, United Kingdom, SW3 6LY
Sponsors and Collaborators
University of Edinburgh
Imperial College London
Principal Investigator: Jeremy P Langrish, MB BCh University of Edinburgh
  More Information

Responsible Party: Jeremy Langrish, Clinical Lecturer and Specialty Registrar in Cardiology, University of Edinburgh Identifier: NCT00738491     History of Changes
Other Study ID Numbers: 08/S1101/6
Study First Received: August 19, 2008
Last Updated: December 1, 2014

Keywords provided by Jeremy Langrish, University of Edinburgh:
Angina pectoris
Exercise capacity
Myocardial ischaemia
Air pollution

Additional relevant MeSH terms:
Heart Diseases
Angina Pectoris
Coronary Disease
Coronary Artery Disease
Myocardial Ischemia
Angina, Stable
Cardiovascular Diseases
Chest Pain
Neurologic Manifestations
Nervous System Diseases
Vascular Diseases
Signs and Symptoms
Arterial Occlusive Diseases processed this record on May 25, 2017