Mechanisms Regulating Wound Vascularization
|ClinicalTrials.gov Identifier: NCT00737321|
Recruitment Status : Active, not recruiting
First Posted : August 19, 2008
Last Update Posted : July 24, 2017
|Condition or disease||Intervention/treatment|
|Wounds and Injuries||Procedure: Samples will be collected|
|Study Type :||Observational|
|Estimated Enrollment :||80 participants|
|Official Title:||Mechanisms Regulating Wound Vascularization|
|Study Start Date :||August 2008|
|Estimated Primary Completion Date :||December 2017|
|Estimated Study Completion Date :||December 2017|
2- Diabetics without wound (s)
These group of subject will be control arm, included who have good glycemic control diabetic with HbA1c 8.4 or lower and also without any open wounds. Samples will be collected.
Procedure: Samples will be collected
wound tissue biopsy, blood samples, saliva collection and wound VAC sponge (if applicable).
1-Subjects with diabetes with wound
This group of subjects will have wound and come for couple of follow up visits for saliva collection, biopsy collection and blood draw.
- Changes in Gene Expression Profile in Healing versus Non-healing Wounds [ Time Frame: 12 weeks ]Wound tissue biopsies, saliva, serum samples and wound sponges will be obtained at an initial time point, at the midpoint of the study and near the end of wound closure over a 12 week window. If the wound closes quickly, i.e. less than 4 weeks then only 2 biopsies will be obtained.
Biospecimen Retention: Samples With DNA
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00737321
|United States, Ohio|
|OSU East Wound Care Center|
|Columbus, Ohio, United States, 43205|
|OSU Comprehensive Wound Care Center Morehouse|
|Columbus, Ohio, United States, 43221|
|Principal Investigator:||Gayle Gordillo, MD||Ohio State University|