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The Effects of Home-Based Rehabilitation Treatments Among Persons With Symptomatic Knee Osteoarthritis

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ClinicalTrials.gov Identifier: NCT00735098
Recruitment Status : Completed
First Posted : August 14, 2008
Last Update Posted : February 6, 2013
Information provided by (Responsible Party):

Study Description
Brief Summary:
Knee Osteoarthritis (OA) is one of the most frequent causes of physical disability and pain among adults. Recent evidence suggests that shorter exercise programs that incorporate kinesthesia, balance and agility (KBA) techniques may result in more rapid symptom relief and functional improvements in comparison to traditional therapeutic exercise. KBA techniques are designed to improve dynamic joint stability by using a series of activities which challenge balance and coordination. To determine the independent effects of KBA training on functional abilities, it is necessary to test it as a training program unto itself. The proposed clinical trial is designed to do this by using three training groups: KBA only; lower extremity strength training only; and a combination of the two. The total exercise time and intensity of each condition will be approximately equal. A non-exercise group will control for any effects related to the testing procedures and the passage of time. Community volunteer men and women age 50 and over with physician diagnosed symptomatic knee OA will participate.

Condition or disease Intervention/treatment
Osteoarthritis Other: KBA exercise Other: strength training exercise Other: KBA and strength training Other: Control group

Study Design

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 44 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Participant)
Primary Purpose: Treatment
Official Title: The Effects of Home-Based Rehabilitation Treatments Among Persons With Symptomatic Knee Osteoarthritis.
Study Start Date : January 2009
Primary Completion Date : December 2012
Study Completion Date : December 2012

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Arms and Interventions

Arm Intervention/treatment
Experimental: 1
KBA exercise protocol
Other: KBA exercise
KBA exercise protocol, 3 times per week for 8 weeks
Experimental: 2
strength training exercise protocol
Other: strength training exercise
strength training exercise, 3 times per week for 8 weeks
Experimental: 3
KBA and strength training protocol
Other: KBA and strength training
KBA and strength training exercise, 3 times per week for 8 weeks
Sham Comparator: 4 Other: Control group
8 week control group

Outcome Measures

Primary Outcome Measures :
  1. (WOMAC) self assessment of physical function [ Time Frame: 8 weeks ]

Eligibility Criteria

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Ages Eligible for Study:   50 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Aged 50 years or over of either gender
  • Self-reported knee pain
  • Physician diagnosed tibiofemoral OA, unilateral or bilateral, per ACR guidelines
  • Demonstrated minimal knee OA related dysfunction per WOMAC score
  • Not engaged in a regular leg exercise program for minimum of 6 months

Exclusion Criteria:

  • High risk health status per (e.g.) ACSM guidelines
  • Inability to obtain physician release for exercise
  • Unresolved balance disorder
  • Unresolved neurological disorder
  • History of knee surgery or major knee trauma injury
  • Hip or ankle instability, excessive weakness, surgery or major trauma injury
  • Hip or knee replacement
  • Intra-articular joint injection within 4 weeks of the study
Contacts and Locations

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To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00735098

United States, Florida
University of Zululand
Saint Petersburg, Florida, United States, 33712
Sponsors and Collaborators
University of Zululand
Principal Investigator: Matthew W Rogers, MS University of Zululand
More Information

Responsible Party: Matthew W. Rogers, MS, Doctoral Student, University of Zululand, University of Zululand
ClinicalTrials.gov Identifier: NCT00735098     History of Changes
Other Study ID Numbers: KneeOAExercise-2
First Posted: August 14, 2008    Key Record Dates
Last Update Posted: February 6, 2013
Last Verified: February 2013

Keywords provided by Matthew W. Rogers, MS, University of Zululand:
Knee Osteoarthritis

Additional relevant MeSH terms:
Osteoarthritis, Knee
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases