Comparing the Use of Vitamin c (Ascorbic Acid) in Eye Burn in Subconjunctival Injection to Topical or Oral Treatment.

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00734695
Recruitment Status : Withdrawn (couldn't recruit patients)
First Posted : August 14, 2008
Last Update Posted : March 2, 2010
Rambam Health Care Campus
Soroka University Medical Center
Information provided by:
The Baruch Padeh Medical Center, Poriya

Brief Summary:
Eye burns may cause a severe permanent damage. One kind of treatment is the use of vitamin C (Ascorbic acid). This study will compare between subconjunctival topical and/or systemic route of administration and topical and/or systemic administration.

Condition or disease Intervention/treatment Phase
Burn Dietary Supplement: vitamin c Phase 1

Detailed Description:

In order to prevent permanent and severe damage to the eye after eye burn early treatment is mandatory. It is well known and published that the use of Vitamin c may contribute to the healing process of such burns, including burns from chemicals or heat. We believe that the route pf administration of the medicine is as important as the kind of medicine and that subconjunctival injection will have better effect and will influence in a favorable manner on the the end result as well as on the time of the healing.

In order to be able to compare between cases we made a new definition of the severity of the burn according to the extension of the damage on the cornea, conjunctiva and limbus, and according to the severity and depth of the ischemia.

In 3 medical centers 3 protocols of treatment and followup will be compared while only in Baruch Pade Medical Center the main route of administration will be subconjunctival on top of the topical treatment.

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 20 participants
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: The Effect of Subconjunctival Vitamin c on Recovery Rate and End Result From Eye Burn.
Study Start Date : July 2009
Estimated Primary Completion Date : November 2009
Estimated Study Completion Date : February 2010

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Burns Vitamin C

Arm Intervention/treatment
Experimental: 1
Baruch Pade Medical Center
Dietary Supplement: vitamin c
Subconjunctival daily or bid
Other Names:
  • subconjunctival
  • ascorbic acid

Active Comparator: 2
Rambam Medical Center
Dietary Supplement: vitamin c
topical and systemic
Other Names:
  • Burn
  • eye
  • ascorbic acid

Active Comparator: 3
Soroka Medical Center
Dietary Supplement: vitamin c
topical systemic
Other Name: burn

Primary Outcome Measures :

Information from the National Library of Medicine

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Ages Eligible for Study:   up to 90 Years   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Eyes clinic patients presented with acute chemical or thermal burn.

Exclusion Criteria:other disease

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00734695

Movshovitz Ina
Afula, Israel
Naftali Modi
Tiberia, Israel
Sponsors and Collaborators
The Baruch Padeh Medical Center, Poriya
Rambam Health Care Campus
Soroka University Medical Center
Principal Investigator: naftali modi, MD Baruch Pade medical center

Responsible Party: Modi Naftali, Baruch Pade Medical Center Identifier: NCT00734695     History of Changes
Other Study ID Numbers: vitcbrn.CTIL
First Posted: August 14, 2008    Key Record Dates
Last Update Posted: March 2, 2010
Last Verified: February 2010

Keywords provided by The Baruch Padeh Medical Center, Poriya:

Additional relevant MeSH terms:
Eye Burns
Wounds and Injuries
Eye Injuries
Facial Injuries
Craniocerebral Trauma
Trauma, Nervous System
Nervous System Diseases
Ascorbic Acid
Growth Substances
Physiological Effects of Drugs
Molecular Mechanisms of Pharmacological Action
Protective Agents