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Study of Histological Samples From Patients With Hereditary Haemorrhagic Telangiectasia

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ClinicalTrials.gov Identifier: NCT00733655
Recruitment Status : Active, not recruiting
First Posted : August 13, 2008
Last Update Posted : May 29, 2015
Sponsor:
Information provided by (Responsible Party):

Study Description
Brief Summary:
Hereditary Haemorrhagic Telangiectasia (HHT, also known as Osler-Weber-Rendu Syndrome) is an disease that leads to the development of dilated and fragile blood vessels. We propose to obtain small skin samples from patients with HHT in order to analyze the samples using histological methods, and study the properties of vascular endothelial cells derived from patients. We hypothesize that these cells will show altered growth, migration, and protein synthetic differences when compared to normal endothelial cells, which may be confirmed in single time point analyses in histological samples. We anticipate that that these findings may help to explain aspects of the HHT disease phenotype.

Condition or disease
Telangiectasia, Hereditary Hemorrhagic

Study Design

Study Type : Observational
Estimated Enrollment : 50 participants
Observational Model: Cohort
Time Perspective: Prospective
Study Start Date : September 2008
Estimated Primary Completion Date : August 2020
Estimated Study Completion Date : August 2020


Groups and Cohorts


Outcome Measures

Biospecimen Retention:   Samples Without DNA
Histological samples

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients with hereditary hemorrhagic telangiectasia (HHT)
Criteria

Inclusion Criteria:

  • Patients with Hereditary Haemorrhagic Telangiectasia

Exclusion Criteria:

  • Unable to provide informed consent
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00733655


Locations
United Kingdom
Imperial College Hammersmith Campus
London, United Kingdom, W12 0NN
Sponsors and Collaborators
Imperial College London
Investigators
Principal Investigator: Claire L Shovlin Imperial College London
More Information

Responsible Party: Imperial College London
ClinicalTrials.gov Identifier: NCT00733655     History of Changes
Other Study ID Numbers: IC/CLS5
First Posted: August 13, 2008    Key Record Dates
Last Update Posted: May 29, 2015
Last Verified: August 2008

Additional relevant MeSH terms:
Telangiectasis
Telangiectasia, Hereditary Hemorrhagic
Vascular Diseases
Cardiovascular Diseases
Hemostatic Disorders
Hemorrhagic Disorders
Hematologic Diseases
Vascular Malformations
Cardiovascular Abnormalities
Congenital Abnormalities