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Surgical Treatment of Hilar Cholangiocarcinoma: Minor or Major Liver Resection?

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00733200
First Posted: August 12, 2008
Last Update Posted: December 11, 2009
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborators:
Ministry of Health, China
Hepatic Surgery Clinical Research Centre of Hubei, China
Information provided by:
Huazhong University of Science and Technology
  Purpose
The investigators conducted a prospective study to determine the safety and efficacy of minor and major hepatectomy selected by predetermined criteria in 138 patients with hilar cholangiocarcinoma. In selected patients, minor liver resection was a good treatment.

Condition Intervention
Cholangiocarcinoma Surgical Treatment Hepatectomy Procedure: Minor or Major Liver Resection

Study Type: Interventional
Official Title: Surgical Treatment of Hilar Cholangiocarcinoma: Minor or Major Liver Resection?

Resource links provided by NLM:


Further study details as provided by Huazhong University of Science and Technology:

Primary Outcome Measures:
  • On multivariate analysis, prognostic factors significantly impacted on long-term survival were UICC tumor stage and histopathologic grade.

Arms Assigned Interventions
No Intervention: Control group Procedure: Minor or Major Liver Resection

Detailed Description:

Objective: To determine the safety and efficacy of minor and major hepatectomy selected by predetermined criteria in patients with hilar cholangiocarcinoma (HC).

Summary Background Data: For HC treated with hepatectomy, the extent of liver resection remains controversial despite extensive studies.

Methods: From January 2000 to December 2007, we prospectively studied patients who received surgical treatment for HC. Of the 187 patients who were surgically treated, 138 (73.8%) underwent resection with a curative intent. Minor hepatectomy was carried out in 93 patients who had Bismuth-Corlette types I, II and III HC without hepatic artery/portal vein invasion; and major hepatectomy in 45 patients who had type III HC with hepatic artery/portal vein invasion, or type IV HC.

  Eligibility

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Ages Eligible for Study:   26 Years to 72 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Criteria for resectability were absence of peritoneal or liver metastases, tumor extension to beyond secondary biliary branches bilaterally, tumor extension to secondary portal venous branches bilaterally

Exclusion Criteria:

  • not in accordance with the above criteria
  Contacts and Locations
No Contacts or Locations Provided
  More Information

ClinicalTrials.gov Identifier: NCT00733200     History of Changes
Other Study ID Numbers: chenxp002
First Submitted: August 8, 2008
First Posted: August 12, 2008
Last Update Posted: December 11, 2009
Last Verified: August 2008

Keywords provided by Huazhong University of Science and Technology:
Minor Liver Resection
Major Liver Resection
Hilar

Additional relevant MeSH terms:
Cholangiocarcinoma
Klatskin Tumor
Adenocarcinoma
Carcinoma
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Neoplasms
Liver Extracts
Hematinics