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Effect of Antioxidant on Endurance Performance in Healthy Men

This study has been completed.
University of California, Davis
Information provided by:
Seoul National University Hospital Identifier:
First received: May 20, 2008
Last updated: August 10, 2008
Last verified: August 2008
oligomerized litchi fruit extract may enhance the submaximal endurance exercise performance

Condition Intervention Phase
Exercise Tolerance
Dietary Supplement: Oligomerized litchi fruit extract
Dietary Supplement: VItamin C + Vitamin E mixture
Other: placebo
Phase 2
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double Blind (Participant, Investigator)
Primary Purpose: Treatment
Official Title: Effect of Antioxidant on Endurance Performance in Healthy Men -Double Blind Randomized Placebo and Active Controlled Trial-

Resource links provided by NLM:

Further study details as provided by Seoul National University Hospital:

Primary Outcome Measures:
  • change of running time to exhaustion under 80% of maximal heart rate [ Time Frame: 1 month ]

Secondary Outcome Measures:
  • VO2max, anaerobic threshold [ Time Frame: 1 month ]

Enrollment: 69
Study Start Date: September 2007
Study Completion Date: February 2008
Primary Completion Date: January 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1 Dietary Supplement: Oligomerized litchi fruit extract
100mg at once twice a day for 1 month
Other Name: oligonol; brand name of oligomerized litchi fruit extract
Active Comparator: 2 Dietary Supplement: VItamin C + Vitamin E mixture
Vitamin C 400mg + Vitamin E 160IU at once twice a day for 1 month
Placebo Comparator: 3 Other: placebo
twice a day for 1 month

Detailed Description:
Regular physical exercise has many beneficial effects, but it has been reported that strenuous exercise could elevate the production of free radical and other reactive oxygen species (ROS) which eventually injure the tissues and decrease the muscle function.So many kinds of antioxidant supplementations have been tried to decrease the muscle fatigue and enhance the exercise performance. polyphenolic flavonoids abundant in fruits and leafy vegetables have strong antioxidant effect. oligomerized litchi fruit extract has strong antioxidant capacity and higher bioavailability compared to that of grape seed polyphenol. The aim of this study was to determine whether oligomerized litchi fruit extract could induce endurance exercise performance more than Vit C + Vit E mixture or placebo could do. Therefore, we designed double blind randomized controlled trial, setting the change of running time to exhaustion under submaximal treadmill test as the primary endpoint.

Ages Eligible for Study:   20 Years to 50 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • healthy men over 20 years old non-smoker

Exclusion Criteria:

  • BMI>25 or body fat>25% he who intakes the antioxidant supplement in recent 2 weeks
  Contacts and Locations
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Please refer to this study by its identifier: NCT00731926

Sponsors and Collaborators
Seoul National University Hospital
University of California, Davis
Principal Investigator: Sang-chul Lee, professor Institute of Complementary Alternative Medicine SNUMC
  More Information

Responsible Party: Sang-chul Lee MD., Ph.D / chief director, Institute of Complementary Alternative Medicine Identifier: NCT00731926     History of Changes
Other Study ID Numbers: H-0707-028-212
Study First Received: May 20, 2008
Last Updated: August 10, 2008

Additional relevant MeSH terms:
Ascorbic Acid
Vitamin E
Growth Substances
Physiological Effects of Drugs
Molecular Mechanisms of Pharmacological Action
Protective Agents processed this record on April 28, 2017