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Evaluation of PET CT in the Management of Patients With Crohn's Disease.

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified February 2008 by Rabin Medical Center.
Recruitment status was:  Recruiting
Information provided by:
Rabin Medical Center Identifier:
First received: August 3, 2008
Last updated: December 22, 2008
Last verified: February 2008
18F-FDG PET/CT (2-[fluorine-18] fluoro-2-deoxy-D-glucose, Positron emission tomography- CT) is a noninvasive technique that allows quantifying and precisely localizing 18F-FDG uptake in the entire body. 18F-FDG uptake is caused by increased local metabolic activity. Such increased uptake has been described not only in neoplastic lesions but also in inflammatory lesions. In this condition, uptake has been correlated with local stimulation of tumor necrosis factor, and with monocyte priming and activation. A physiologic variable uptake may be observed in the bowel, especially the cecum, and has limited the use of PET in inflammatory bowel diseases. The advantage of combined PET and CT devices lead to significant improvements in the interpretation of the bowel areas, and greatly reduces the number of false-positive findings in the gastrointestinal tract.

Condition Intervention Phase
Crohn's Disease Radiation: FDG PET CT Phase 4

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Diagnostic
Official Title: Evaluation of PET CT in the Management of Patients With Crohn's Disease.

Resource links provided by NLM:

Further study details as provided by Rabin Medical Center:

Estimated Enrollment: 50
Study Start Date: April 2008
Estimated Study Completion Date: October 2010
Estimated Primary Completion Date: April 2010 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Radiation: FDG PET CT


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Patients suspicious for active disease:

    • Patients with suspected but undiagnosed Crohn's disease
    • Patients with serological markers of inflammation (elevated ESR, CRP or thrombocytosis) but clinically in remission
    • Patients with a stricture which might be fibrous in which case surgery is indicated or inflammatory for which medical management is indicated
    • Able to sign a consent form

Exclusion Criteria:

  • Pregnancy
  • Breastfeeding
  • Infectious colitis determined at the initial checkup
  • Allergy to iodine contrast
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00731809

Rabin Medical Center Recruiting
Petah-tikva, Israel, 49100
Contact: Bernstine, MD   
Principal Investigator: Hanna Bernstine, MD         
Sponsors and Collaborators
Rabin Medical Center
  More Information

Responsible Party: Hanna Brrnstine MD, Beilinson Hospital Rabin Medical Center Identifier: NCT00731809     History of Changes
Other Study ID Numbers: 004945
Study First Received: August 3, 2008
Last Updated: December 22, 2008

Keywords provided by Rabin Medical Center:
Crohn's disease

Additional relevant MeSH terms:
Crohn Disease
Inflammatory Bowel Diseases
Gastrointestinal Diseases
Digestive System Diseases
Intestinal Diseases processed this record on July 21, 2017