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Sperm Capacitation Assay as a Tool to Predict Sperm Potential to Fertilize in IVF Treatment

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ClinicalTrials.gov Identifier: NCT00731159
Recruitment Status : Unknown
Verified July 2008 by Assaf-Harofeh Medical Center.
Recruitment status was:  Recruiting
First Posted : August 8, 2008
Last Update Posted : August 8, 2008
Sponsor:
Information provided by:
Assaf-Harofeh Medical Center

Brief Summary:
Our aim is to evaluate the potential of a new laboratory method that measure sperm capacitation to predict fertilization of oocytes in patients that undergo IVF treatments

Condition or disease Intervention/treatment
Sperm Capacitation Biological: sperm capacitation Other: biologic Other: sperm capacitation

Detailed Description:
Capacitation is a physiologic process in which the sperm acquire the potential to fertilize oocytes. Capacitation can be measured, but the available technics are expensive, inaccurate and complex. A new method to evaluate sperm capacitation was developed in Bar Ilan University, Israel. We intend to measure the capacitation of semen that is used for fertilizing human oocytes in patients treated at the IVF unit at Assaf Harofeh Medical Center.By this, to evaluate the potential of the new method to predict human oocyte fertilization.If the method will be found valuable, it will enable to develop new drugs/methods that may improve sperm capacitation and by this to improve oocyte fertilization leading to more embryos, pregnancies and deliveries.

Study Type : Observational
Estimated Enrollment : 50 participants
Time Perspective: Prospective
Official Title: Sperm Capacitation Assay as a Tool to Predict Sperm Potential to Fertilize in IVF Treatment
Study Start Date : July 2008
Estimated Primary Completion Date : January 2009
Estimated Study Completion Date : July 2009

Group/Cohort Intervention/treatment
A

Sperm capacitation:

Sperm capacitation is measured in a sample of the same ejaculated sperm unit given for fertilizing human oocytes in an IVF treatment cycle

Biological: sperm capacitation
sperm capacitation measured at Bar Ilan University
Other: biologic
sperm synthesis of G-actine to F-actine
Other Name: sperm capacitation
Other: sperm capacitation
sperm synthesis of G-actine to F-actine
Other Name: sperm synthesis of G-actine to F-actine



Primary Outcome Measures :
  1. Fertilization rate of human oocytes in thr "routine" IVF Laboratory work [ Time Frame: One year ]


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Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Patients requiring IVF within the "routine" work of an IVF Unit
Criteria

Inclusion Criteria:

  • Patients requiring IVF within the "routine" work of an IVF Unit
  • normo-responding woman
  • non ICSI cycles

Exclusion Criteria:

  • Patients undergoing ICSI only cycle
  • Low responders-less than 8 oocytes
  • Male patients with low semen volume

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00731159


Contacts
Contact: arieh raziel, prof 97289779005 araziel@asaf.health.gov.il
Contact: raphael ron-el, prof 97289779005 rronel@asaf.health.gov.il

Locations
Israel
Assaf Harofeh MC Recruiting
Beer Yaacov, Zerifin, Israel, 70300
Contact: arieh raziel, prof    97289779005    araziel@asaf.health.gov.il   
Contact: raphael ron-el, prof    97289779005    rronel@asaf.health.gov.il   
Principal Investigator: arieh raziel, prof         
Sub-Investigator: raphael ron-el, prof         
Sponsors and Collaborators
Assaf-Harofeh Medical Center

Responsible Party: Prof A Raziel, Assaf Harofeh MC
ClinicalTrials.gov Identifier: NCT00731159     History of Changes
Other Study ID Numbers: 54/08
First Posted: August 8, 2008    Key Record Dates
Last Update Posted: August 8, 2008
Last Verified: July 2008