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Sperm Capacitation Assay as a Tool to Predict Sperm Potential to Fertilize in IVF Treatment

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified July 2008 by Assaf-Harofeh Medical Center.
Recruitment status was:  Recruiting
Information provided by:
Assaf-Harofeh Medical Center Identifier:
First received: August 7, 2008
Last updated: NA
Last verified: July 2008
History: No changes posted
Our aim is to evaluate the potential of a new laboratory method that measure sperm capacitation to predict fertilization of oocytes in patients that undergo IVF treatments

Condition Intervention
Sperm Capacitation
Biological: sperm capacitation
Other: biologic
Other: sperm capacitation

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Sperm Capacitation Assay as a Tool to Predict Sperm Potential to Fertilize in IVF Treatment

Further study details as provided by Assaf-Harofeh Medical Center:

Primary Outcome Measures:
  • Fertilization rate of human oocytes in thr "routine" IVF Laboratory work [ Time Frame: One year ]

Estimated Enrollment: 50
Study Start Date: July 2008
Estimated Study Completion Date: July 2009
Estimated Primary Completion Date: January 2009 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions

Sperm capacitation:

Sperm capacitation is measured in a sample of the same ejaculated sperm unit given for fertilizing human oocytes in an IVF treatment cycle

Biological: sperm capacitation
sperm capacitation measured at Bar Ilan University
Other: biologic
sperm synthesis of G-actine to F-actine
Other Name: sperm capacitation
Other: sperm capacitation
sperm synthesis of G-actine to F-actine
Other Name: sperm synthesis of G-actine to F-actine

Detailed Description:
Capacitation is a physiologic process in which the sperm acquire the potential to fertilize oocytes. Capacitation can be measured, but the available technics are expensive, inaccurate and complex. A new method to evaluate sperm capacitation was developed in Bar Ilan University, Israel. We intend to measure the capacitation of semen that is used for fertilizing human oocytes in patients treated at the IVF unit at Assaf Harofeh Medical Center.By this, to evaluate the potential of the new method to predict human oocyte fertilization.If the method will be found valuable, it will enable to develop new drugs/methods that may improve sperm capacitation and by this to improve oocyte fertilization leading to more embryos, pregnancies and deliveries.

Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Patients requiring IVF within the "routine" work of an IVF Unit

Inclusion Criteria:

  • Patients requiring IVF within the "routine" work of an IVF Unit
  • normo-responding woman
  • non ICSI cycles

Exclusion Criteria:

  • Patients undergoing ICSI only cycle
  • Low responders-less than 8 oocytes
  • Male patients with low semen volume
  Contacts and Locations
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Please refer to this study by its identifier: NCT00731159

Assaf Harofeh MC
Beer Yaacov, Zerifin, Israel, 70300
Sponsors and Collaborators
Assaf-Harofeh Medical Center
  More Information

Responsible Party: Prof A Raziel, Assaf Harofeh MC Identifier: NCT00731159     History of Changes
Other Study ID Numbers: 54/08 
Study First Received: August 7, 2008
Last Updated: August 7, 2008 processed this record on February 20, 2017