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Association Study of Gene Polymorphisms With Cardiac Performance

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified August 2008 by University Hospital, Essen.
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT00730899
First Posted: August 8, 2008
Last Update Posted: August 8, 2008
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
University Hospital, Essen
  Purpose
The purpose of this study is to determine whether polymorphisms in G protein subunits, namely Galphas and Galphaq, are associated with altered cardiac performance in heart failure patients.

Condition
Genetic Polymorphism Coronary Artery Disease Hemodynamics

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Observational Association Study of G Protein Polymorphisms With Cardiac Performance in Coronary Artery Disease Patients Undergoing Coronary Artery Bypass Grafting

Further study details as provided by University Hospital, Essen:

Primary Outcome Measures:
  • genotype dependent change of hemodynamic variables [ Time Frame: one day ]

Secondary Outcome Measures:
  • all cause mortality [ Time Frame: 60 days ]

Biospecimen Retention:   Samples With DNA
whole blood

Estimated Enrollment: 500
Study Start Date: May 2008
Estimated Study Completion Date: June 2011
Estimated Primary Completion Date: January 2011 (Final data collection date for primary outcome measure)
Detailed Description:
G Protein pathways plays a pivotal role in mediating positive inotropy and cardiac hypertrophy by transducing signals of neurohormones in cardiomyocytes. Single nucleotide polymorphisms (SNPs) in the G protein subunits Galphas and Galphaq have been shown to result in altered protein expression. We now want to examine whether G Protein polymorphisms alter NYHA functional class, and hemodynamic variables in patients with coronary artery disease scheduled for coronary artery bypass grafting .
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients with coronary artery disease scheduled for coronary artery bypass grafting in the university hospital
Criteria

Inclusion Criteria:

  • clinical diagnosis of coronary artery disease
  • patients scheduled for coronary artery bypass grafting

Exclusion Criteria:

  • emergency operation
  • combined vitium
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00730899


Contacts
Contact: Ulrich H Frey, MD +49201723 ext 1401 ulrich.frey@uk-essen.de

Locations
Germany
University Hospital Recruiting
Essen, Nordrhein-Westfalen, Germany, 45147
Contact: Ulrich H Frey, MD    +49201723 ext 1401    ulrich.frey@uk-essen.de   
Principal Investigator: Jürgen Peters, MD         
Sponsors and Collaborators
University Hospital, Essen
Investigators
Study Director: Jürgen Peters, MD University Hospital, Essen
  More Information

Additional Information:
Responsible Party: Ulrich Frey, University Hospital Essen
ClinicalTrials.gov Identifier: NCT00730899     History of Changes
Other Study ID Numbers: HOT-001
First Submitted: August 4, 2008
First Posted: August 8, 2008
Last Update Posted: August 8, 2008
Last Verified: August 2008

Additional relevant MeSH terms:
Coronary Artery Disease
Myocardial Ischemia
Coronary Disease
Heart Diseases
Cardiovascular Diseases
Arteriosclerosis
Arterial Occlusive Diseases
Vascular Diseases