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Injection of Day 2 Embryo Culture Supernatant Into the Uterine Cavity Didn't Improve Implantation and Pregnancy Rates

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00730496
First Posted: August 8, 2008
Last Update Posted: November 5, 2010
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Shen-Zhen City Maternity and Child Healthcare Hospital
  Purpose
Forty-five infertile women undergoing in vitro fertilization treatment were managed by uterine cavity injection of day 2 embryo culture supernatant before day 3 embryo transfer. No statistically significant differences were found in implantation and pregnancy rates when compared with control group.

Condition Intervention Phase
Infertility In Vitro Fertilization Procedure: uterine cavity injection of day 2 embryo culture supernatant Phase 1

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Participant)
Primary Purpose: Treatment
Official Title: Injection of Day 2 Embryo Culture Supernatant Into the Uterine Cavity Didn't Improve Implantation and Pregnancy Rates of Day 3 Embryo Transfer: a Randomized Clinical Trial in Patients Who Underwent in Vitro Fertilization- Embryo Transfer.

Further study details as provided by Shen-Zhen City Maternity and Child Healthcare Hospital:

Primary Outcome Measures:
  • The clinical pregnancy rate and embryo implantation rate. [ Time Frame: two months ]

Enrollment: 90
Study Start Date: January 2008
Study Completion Date: July 2008
Primary Completion Date: July 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1
the study group, 45 women
Procedure: uterine cavity injection of day 2 embryo culture supernatant
On the day 2, the embryos were translated from the old dish to a new dish with fresh media and cultured continuously. In study group, the embryo culture supernatant at the old dish were aspirated by using embryo transfer catheter (COOK-5000, Australia) and injected into the patient's uterine cavity. But in the control group, this intervention was not done. Conventional ET was performed on the third day of embryo culture for both groups.
No Intervention: 2
the control group, 45 women

  Show Detailed Description

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   23 Years to 39 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • The participants were only those women who were first going to undergo IVF or ICSI treatment.

Exclusion Criteria:

  • The women who were treated with natural cycle IVF or had no appropriate embryo for ET were excluded.
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00730496


Locations
China, Guang-Dong
Department of Reproductive Centre, Shen-Zhen Maternity and Child Healthcare Hospital
Shenzhen, Guang-Dong, China, 518048
Sponsors and Collaborators
Shen-Zhen City Maternity and Child Healthcare Hospital
Investigators
Study Chair: Wen-Jie Zhu, M.D ShenZhen Maternity and Child Healthcare Hospital
  More Information

Responsible Party: Wen-Jie Zhu, Shen-Zhen City Maternity and Child Healthcare Hospital
ClinicalTrials.gov Identifier: NCT00730496     History of Changes
Other Study ID Numbers: 200803889
First Submitted: July 31, 2008
First Posted: August 8, 2008
Last Update Posted: November 5, 2010
Last Verified: August 2008

Keywords provided by Shen-Zhen City Maternity and Child Healthcare Hospital:
Embryo culture supernatant
injection
embryo transfer
embryo implantation rate

Additional relevant MeSH terms:
Infertility
Genital Diseases, Male
Genital Diseases, Female