Paclitaxel Albumin-Stabilized Nanoparticle Formulation and Carboplatin in Treating Patients With Stage IIIB, Stage IV, or Recurrent Non-Small Cell Lung Cancer
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ClinicalTrials.gov Identifier: NCT00729612 |
Recruitment Status
:
Completed
First Posted
: August 7, 2008
Results First Posted
: June 6, 2016
Last Update Posted
: April 2, 2018
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RATIONALE: Drugs used in chemotherapy, such as paclitaxel albumin-stabilized nanoparticle formulation and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells.
PURPOSE: This phase II trial is studying how well paclitaxel albumin-stabilized nanoparticle formulation given together with carboplatin works in treating patients with stage IIIB, stage IV, or recurrent non-small cell lung cancer.
Condition or disease | Intervention/treatment | Phase |
---|---|---|
Lung Cancer | Drug: carboplatin Drug: paclitaxel albumin-stabilized nanoparticle formulation Genetic: protein expression analysis Other: immunoenzyme technique Other: immunohistochemistry staining method Other: laboratory biomarker analysis | Phase 2 |
OBJECTIVES:
Primary
- To determine the response rate, in terms of overall response rate (complete response and partial response), of paclitaxel albumin-stabilized nanoparticle formulation and carboplatin in patients with stage IIIB-IV or recurrent non-small cell lung cancer who are ineligible for treatment with bevacizumab.
Secondary
- To evaluate safety of this regimen in these patients.
- To describe the overall survival of these patients.
- To describe progression-free survival of these patients.
Tertiary Objectives
- To explore, in a pilot fashion, the activity of this regimen using predictive biomarkers including serum SPARC levels, methylation of SPARC in primary tumor samples and serum, Ras mutations, ERCC1 and SPARC immunohistochemistry, and serum miRNA expression profiles.
OUTLINE: Patients receive paclitaxel albumin-stabilized nanoparticle formulation IV over 30 minutes and carboplatin IV over 1-2 hours on day 1. Treatment repeats every 21 days for up to 6 courses in the absence of disease progression or unacceptable toxicity.
Paraffin-embedded tissue blocks or unstained slides and blood samples are collected for correlative studies. Samples are analyzed for serum SPARC by ELISA, Ras mutations, ERCC1 AND SPARC by immunohistochemistry, and serum miRNA expression profiling.
After completion of study treatment, patients are followed periodically.
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 63 participants |
Intervention Model: | Single Group Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Treatment |
Official Title: | Phase II Trial of Abraxane Plus Carboplatin for Advanced NSCLC for Patients at Risk of Bleeding From VEGF Directed Therapies |
Actual Study Start Date : | August 14, 2008 |
Actual Primary Completion Date : | December 16, 2011 |
Actual Study Completion Date : | December 16, 2011 |

Arm | Intervention/treatment |
---|---|
Experimental: Treatment (nab-paclitaxel, carboplatin)
Patients receive paclitaxel albumin-stabilized nanoparticle formulation IV over 30 minutes and carboplatin IV over 1-2 hours on day 1. Treatment repeats every 21 days for up to 6 courses in the absence of disease progression or unacceptable toxicity.
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Drug: carboplatin Drug: paclitaxel albumin-stabilized nanoparticle formulation Genetic: protein expression analysis Other: immunoenzyme technique Other: immunohistochemistry staining method Other: laboratory biomarker analysis |
- Overall Response Rate Defined as Complete or Partial Response as Assessed by RECIST Version 1.0 Criteria. [ Time Frame: Up to 5 years ]Response rate is overall response rate (CR+PR) as defined by RECIST criteriaPer Response Evaluation Criteria In Solid Tumors Criteria (RECIST v1.0) for target lesions and assessed by MRI: Complete Response (CR), Disappearance of all target lesions; Partial Response (PR), >=30% decrease in the sum of the longest diameter of target lesions; Overall Response (OR) = CR + PR.
- Progression Free Survival [ Time Frame: Up to 5 years ]Progression is defined using Response Evaluation Criteria In Solid Tumors Criteria (RECIST v1.0), as a 20% increase in the sum of the longest diameter of target lesions, or a measurable increase in a non-target lesion, or the appearance of new lesions
- Overall Survival [ Time Frame: Up to 5 years ]Will be analyzed using a Kaplan-Meier methods.
- Incidence and Intensity of Adverse Events Graded According to NCI CTCAE v. 3.0 [ Time Frame: Up to 5 years ]The incidence and intensity of adverse events graded according to NCI CTCAE v. 3.0 will be evaluated using descriptive statistics

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Ages Eligible for Study: | 18 Years to 120 Years (Adult, Senior) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
DISEASE CHARACTERISTICS:
-
Histologically or cytologically confirmed advanced non-small cell lung cancer (NSCLC) meeting 1 of the following criteria:
- Stage IIIB disease with malignant pleural effusion
- Stage IV disease
- Recurrent disease
- Squamous cell histology allowed
- Not eligible for curative treatment or treatment with bevacizumab
- Measurable disease according to RECIST
- Tumor (paraffin blocks or slides) must be available for correlative biomarker studies
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No uncontrolled brain metastases (or leptomeningeal disease)
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Controlled brain metastases allowed
- Able to receive appropriate therapeutic radiotherapy
- Able to taper off all steroids without symptoms suggestive of increased intracranial pressure (nausea, vomiting, focal neurologic symptoms) for at least 7 days
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PATIENT CHARACTERISTICS:
- ECOG (Eastern Cooperative Oncology Group) performance status 0-2
- ANC (absolute neutrophil count) ≥ 1.5 x 10^9/L
- Platelets ≥ 100 x 10^9/L
- Hemoglobin ≥ 9.0 g/L
- Total bilirubin ≤ 1.5 mg/dL
- AST (aspartate aminotransferase) and ALT (alanine aminotransferase) < 2.5 times upper limit of normal
- Creatinine ≤ 1.5 mg/dL OR creatinine clearance > 50 mg/mL
- No known HIV or hepatitis B or C
- Not pregnant
- Negative pregnancy test
- Thrombotic or embolic event within the past 6 months allowed, provided adequately controlled with therapeutic anticoagulation
- Hemoptysis allowed, provided it is not life threatening or requires palliative procedures (e.g., endobronchial therapy or radiotherapy)
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No cardiac disease, including any of the following:
- NYHA (New York Heart Association) class III-IV congestive heart failure
- Unstable angina (angina symptoms at rest)
- New onset angina (began within the past 3 months)
- Myocardial infarction within the past 6 months
- No uncontrolled hypertension, defined as systolic blood pressure (BP) > 150 mm Hg or diastolic BP > 90 mm Hg despite optimal medical management
- No peripheral neuropathy ≥ grade 2
- No active clinically serious infection > CTCAE grade 2
- No serious non-healing wound, ulcer, or bone fracture
- No significant traumatic injury within the past 4 weeks
- No evidence or history of bleeding diathesis or coagulopathy
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No prior malignancy, except for adequately treated basal cell skin cancer, carcinoma in situ of the cervix, or other cancer for which the patient has been disease-free for 2 years
- Stage I (T1c) prostate cancer adequately treated 2 years prior to diagnosis of NSCLC allowed, however metastatic prostate cancer currently receiving hormonal therapy or chemotherapy is not allowed
- No significant psychiatric illness, in the opinion of the principal investigator, that would prevent adequate informed consent or render therapy unsafe
PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
- Concurrent therapeutic anticoagulation, > 325 mg acetylsalicylic acid, or chronic non-steroid anti-inflammatory drug use allowed
- At least 14 days since prior and no concurrent radiotherapy
- More than 4 weeks since prior major surgery or open biopsy

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00729612
United States, Ohio | |
Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center | |
Columbus, Ohio, United States, 43210 |
Principal Investigator: | Gregory A. Otterson, MD | Ohio State University Comprehensive Cancer Center |
Additional Information:
Publications of Results:
Responsible Party: | Greg Otterson, Principal Investigator, Ohio State University Comprehensive Cancer Center |
ClinicalTrials.gov Identifier: | NCT00729612 History of Changes |
Other Study ID Numbers: |
OSU-08059 NCI-2011-03196 ( Registry Identifier: Clinical Trials Reporting Program (CTRP) ) |
First Posted: | August 7, 2008 Key Record Dates |
Results First Posted: | June 6, 2016 |
Last Update Posted: | April 2, 2018 |
Last Verified: | March 2018 |
Keywords provided by Greg Otterson, Ohio State University Comprehensive Cancer Center:
stage IIIB non-small cell lung cancer stage IV non-small cell lung cancer recurrent non-small cell lung cancer squamous cell lung cancer |
Additional relevant MeSH terms:
Lung Neoplasms Carcinoma, Non-Small-Cell Lung Respiratory Tract Neoplasms Thoracic Neoplasms Neoplasms by Site Neoplasms Lung Diseases Respiratory Tract Diseases Carcinoma, Bronchogenic Bronchial Neoplasms |
Paclitaxel Albumin-Bound Paclitaxel Carboplatin Antineoplastic Agents, Phytogenic Antineoplastic Agents Tubulin Modulators Antimitotic Agents Mitosis Modulators Molecular Mechanisms of Pharmacological Action |