The Therapeutic Efficacy of Neurofeedback in Depression (neurofeedback)
The investigators examined the therapeutic efficacy of neurofeedback in depression subjects. The investigators hypothesize that 5 weeks neurofeedback training will be able to alleviate depressive symptoms.
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Factorial Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||The Therapeutic Efficacy of Frontal EEG Asymmetry Neurofeedback in Depression|
- frontal EEG asymmetry indexes [ Time Frame: 5 weeks ] [ Designated as safety issue: No ]
- BDI-2 [ Time Frame: 5 weeks ] [ Designated as safety issue: No ]
|Study Start Date:||September 2006|
|Study Completion Date:||January 2007|
|Primary Completion Date:||December 2006 (Final data collection date for primary outcome measure)|
Placebo Comparator: 2
Psychotherapy placebo session
Behavioral: Psychotherapy placebo
These sessions consisted of additional assessment, interpretation of the test results and providing information on course and treatment of mood disorder.
Neurofeedback training which enhance left frontal alpha wave.
enhance relative activity level of left frontal activity
Other Name: Asymmetry training
- Fulfilled DSM-IV criteria for depressive disorders.
- Persons who had organic disorders were excluded.
- Who had been treated by psychoactive drugs for at least 2 months prior to the study were excluded.
- Subjects were randomly assigned to two groups (EEG biofeedback /psychotherapy placebo) by block randomization.
- EEG biofeedback training was provided for 5 weeks(10 sessions, twice per week). Each training session was composed of 6 four minute trials followed by 5 thirty second rest periods
- Psychotherapy placebo session was provided for 5 weeks. These sessions consisted of additional assessment, interpretation of the test results and providing information on course and treatment of mood disorder.
- After subjects completed the training, they participated in a month-long (twice per week) self-training session to maintain a similar mental state during neurofeedback training sessions without feedback system's assistance.
- Subjects who had finished the psychotherapy placebo were referred to other therapists as necessary.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00729547
|Korea, Republic of|
|Department of Oriental Neuropsychiatry, Kyunghee Medical Center|
|Seoul, Korea, Republic of, 130-702|
|Principal Investigator:||Hyuntaek Kim, PHD||Department of Psychology, Korea university|