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The Effect of Pomegranate Juice on Oxidative Stress in Hemodialysis Patients

This study has been completed.
Information provided by:
Western Galilee Hospital-Nahariya Identifier:
First received: July 27, 2008
Last updated: March 22, 2010
Last verified: March 2010
Pomegranate juice (PJ) consumption by hemodialysis patients will reduce the oxidative stress and the incidence of infections, cardiovascular events and mortality.

Condition Intervention Phase
End Stage Renal Disease
Dietary Supplement: Pomegranate juice
Dietary Supplement: Placebo
Phase 3

Study Type: Interventional
Study Design: Primary Purpose: Prevention
Official Title: A Randomized Clinical Trial for Estimating the Effects of Pomegranate Juice Consumption by Hemodialysis Patients on Oxidative Stress, Infections, Cardiovascular Events and Mortality

Resource links provided by NLM:

Further study details as provided by Western Galilee Hospital-Nahariya:

Study Start Date: July 2008
Study Completion Date: January 2010
Arms Assigned Interventions
Experimental: PG Dietary Supplement: Pomegranate juice
Experimental: PL Dietary Supplement: Placebo

Detailed Description:

The mortality rate in patients with end stage renal failure is substantially higher than in the general population, and deaths are mainly attributable to cardiovascular diseases and infections. There is accumulating evidence that supports the role for oxidative stress in damaging the immune system and in the pathogenesis of cardiovascular diseases in hemodialysis patients, therefore antioxidative treatment, which will reduce oxidative stress, may be beneficial.

Pomegranate juice contains antioxidants such as soluble polyphenols, tannins and anthocyanins and was shown to have anti-inflammatory, anti- bacterial and anti-atherosclerotic properties in mice and humans. However,the effects of pomegranate juice on oxidative stress, infections and cardiovascular events in hemodialysis patients are still not documented.

This is a randomized preventive intervention trial on hemodialysis patients from one dialysis centre in Israel. The patients will be enrolled and randomized to receive pomegranate juice or placebo. Patients will be followed for one year. The objective of this study is to investigate the effects of pomegranate juice (PJ) consumption by hemodialysis patients on the changes in oxidative stress and the incidence of infections, cardiovascular events and mortality.


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • End Stage Renal Disease, stable chronic hemodialysis > 3 months
  • Informed Consent.
  • Man and women over 18 years.

Exclusion Criteria:

  • Hemodialysis < 3 months
  • Participation in other clinical trial
  • Not eligible according to physician decision
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Please refer to this study by its identifier: NCT00727519

Western Galilee hospital
Nahariya, Israel, 22100
Sponsors and Collaborators
Western Galilee Hospital-Nahariya
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Prof. Batya Kristal, Western Galilee Hospital-Nahariya Identifier: NCT00727519     History of Changes
Other Study ID Numbers: PJHD-23-7-08CTIL
Study First Received: July 27, 2008
Last Updated: March 22, 2010

Keywords provided by Western Galilee Hospital-Nahariya:
Pomegranate Juice

Additional relevant MeSH terms:
Kidney Failure, Chronic
Renal Insufficiency, Chronic
Renal Insufficiency
Kidney Diseases
Urologic Diseases processed this record on May 24, 2017