Serum Procalcitonin Study in the Management of Ventilated Patients
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The purpose of this study is to test a new method for diagnosing and monitoring Ventilator-Associated Pneumonia, which is a major killer among ICU patients. The method requires analysis of a small amount of the patient's blood for concentration of a hormone called Procalcitonin.
Condition or disease
Ventilator Associated Pneumonia
Device: Procalcitonin Level
Ventilator-associated pneumonia is a leading cause of mortality in critically ill patients. The purpose of this study is to evaluate the relationship between the onset/progress/resolution of pneumonia and the levels of Procalcitonin, a prohormone whose concentrations fluctuate in response to bacterial infection.
Procalcitonin concentrations will be determined every day and will be compared with the clinical diagnosis based upon standard clinical practice. All subjects enrolled will be followed until the patient is either extubated or discharged from the SICU.
Correlation of Procalcitonin concentration with the LungGuardian-derived Pneumonia Score in mechanically ventilated surgical intensive care unit patients. Using the data collected a positive and negative predictive value will be calculated. [ Time Frame: Once daily ]
Secondary Outcome Measures :
antibiotic status (appropriateness, effectiveness, discontinuation criteria) [ Time Frame: Once daily ]
intubation date [ Time Frame: Once daily ]
microbiology data [ Time Frame: Once daily ]
PCT levels [ Time Frame: Once daily ]
pneumonia-related symptoms (including tracheal secretion character, body temperature, oxygenation, and WBC counts) [ Time Frame: Once daily ]
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Ages Eligible for Study:
18 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
mechanically ventilated surgical intensive care unit patients
Are willing to give or who's proxy is willing to consent to be a study subject
Are at least 18 years of age;
Who are mechanically ventilated surgical intensive care unit patients.
Participation in any investigational device or drug trial within 30 days prior to enrollment.
Mueller B and Prat C. Markers in acute inflammation in assessing and managing lower respiratory tract infections; focus on procalcitonin. Clin Microbiol Infect 2006; 12(Suppl):8-16
Phillips JO, Metzler MH, Huckfeldt RE, Keller ME, McBride CL. A Prospective evaluation of a simple disease management plan for nosocomial pneumonia in the ventilated trauma patient. Crit Care Med 1999: 27: 143