Case Control Study: Determinants of Osteoporosis in GOLD II COPD Patients.
Patients with COPD have been found to have an increased risk of osteoporosis. The underlying mechanism is not clear yet. This case control study aims to identify risk factors for osteoporosis in GOLD II COPD patients. COPD GOLD II patients with osteoporosis (cases) will be matched by gender and age to COPD GOLD II patients without osteoporosis(controls).
Possible risk factors for osteoporosis are:
- BMI/VVMI (body composition)
- emphysema vs chronic bronchitis
- physical capacity
- Use of certain medication (eg corticosteroids, SSRI's)
- Nutritional status
- Infectious parameters Outpatients from the pulmonary ward of the Catharina Hospital Eindhoven with GOLD II COPD according to the ATS and GOLD-guidelines will be included in the study (after written informed consent).
A DEXA-scan will be made, if patients are osteoporotic or have a normal BMD they will be included in the study.
A HRCT will be made, a six minutes walking distance will be performed, blood will be drawn for lab. analysis, an X-ray of the vertebral collum will be made, impedance will be measured and hight and weight will be measuered. Also patients will fill in a questionaire.
By univariate and multivariate analysis the collected data will be analysed to determine possible risk factors for th development of osteoporosis in COPD GOLD II patients.
Chronic Obstructive Pulmonary Disease
|Study Design:||Observational Model: Case Control
Time Perspective: Cross-Sectional
|Official Title:||Determination of Risk Factors for Developing Osteoporosis in COPD GOLD II Patients. A Case Control Study to Identify Possible Risk Factors for Developing Osteoporosis in COPD GOLD II Patients.|
- Risk factors for osteoporosis in GOLD II COPD patients [ Time Frame: 1 year ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples Without DNA
|Study Start Date:||September 2007|
|Study Completion Date:||June 2009|
|Primary Completion Date:||April 2009 (Final data collection date for primary outcome measure)|
GOLD II COPD patients with osteoporosis
GOLD II COPD patients with a normal bone mineral density
Please refer to this study by its ClinicalTrials.gov identifier: NCT00725673
|Catharina Hospital Eindhoven|
|Eindhoven, Noord-Brabant, Netherlands, 5623 EJ|
|Principal Investigator:||Lidwien Graat-Verboom||Catharina Ziekenhuis Eindhoven|