Evaluation of the Efficacy of Acitretin Therapy for Nail Psoriasis
|ClinicalTrials.gov Identifier: NCT00723437|
Recruitment Status : Completed
First Posted : July 28, 2008
Last Update Posted : July 28, 2008
Efficacy of systemic retinoid therapy of nail psoriasis has never been assessed objectively. Evaluate therapeutic efficacy of acitretin in patients with isolated nail psoriasis.
Open-study on thirty-six patients with moderate to severe nail psoriasis treated with acitretin.
Patients included 27 men and 9 women (mean age 41) with nail psoriasis. Intervention: Therapy consisted of acitretin 0.2 to 0.3 mg/Kg/day for 6 months.
Main Outcome Measure(s):
Clinical evaluation, NAPSI and modified NAPSI scores before therapy, every 2 months during therapy and 6 months after treatment.
|Condition or disease||Intervention/treatment||Phase|
|Psoriasis||Drug: acitretin||Phase 4|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||36 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Evaluation of Nail Psoriasis Severity Index (NAPSI) and Modified Napsi in Patients With Nail Psoriasis Treated With Acitretin|
|Study Start Date :||January 2005|
|Actual Primary Completion Date :||January 2007|
|Actual Study Completion Date :||July 2008|
- Drug: acitretin
Acitretin at the dosage of 0.2 to 0.3 mg/Kg/day for 6 months.Other Name: Neotigason
- correlate clinical improvement with % reduction in the NAPSI Score [ Time Frame: 6 months ]
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00723437
|Department of Dermatology University of Bologna|
|Bologna, Italy, 40138|
|Principal Investigator:||Antonella Tosti, MD||University of Bologna|