Comparison of CT Angiography With Conventional Angiography and Intravascular Ultrasound in Heart Transplant Patients
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|ClinicalTrials.gov Identifier: NCT00723281|
Recruitment Status : Completed
First Posted : July 28, 2008
Last Update Posted : August 19, 2014
The overall goal of this study is to determine if non-invasive imaging with state of the art CT coronary angiography can be used to screen for transplant coronary artery disease in the setting of heart transplant.
Our current protocol at UCSF for heart transplant patients involves screening with stress tests as well as coronary angiograms with intravascular ultrasound to assess the diameter of the lumen of the coronary arteries and to assess wall thickness.
|Condition or disease|
|Heart Transplantation Coronary Artery Disease|
Our hypothesis is that state of the art CT coronary angiography can be used to acquire data regarding the coronary arteries in the setting of heart transplant and be used to risk stratify patients with regards to the developments of transplant coronary artery disease.
Specific Aim 1- To test the hypothesis that coronary CTA can accurately measure cross-sectional vessel wall area using conventional coronary angiography with intra-vascular ultrasound as the standard of reference.
Specific Aim 2- To test the hypothesis that coronary CTA can accurately measure cross-sectional vessel wall thickness, vessel area and luminal area using conventional coronary angiography with intra-vascular ultrasound as the standard of reference.
Secondary Aim - To asses the correlation of cross-sectional vessel wall area, vessel wall thickness, vessel area, luminal area and vessel wall index with global and regional left ventricular function using coronary CTA.
|Study Type :||Observational|
|Estimated Enrollment :||18 participants|
|Official Title:||Comparison of CT Angiography With Conventional Angiography and Intravascular Ultrasound in Heart Transplant Patients|
|Study Start Date :||January 2007|
|Actual Primary Completion Date :||July 2010|
|Actual Study Completion Date :||April 2013|
- Based on these considerations, 18 patients will be recruited to participate in this study, including at least 10 patients with coronary allograft vasculopathy. Only CTA of patients with positive echocardiographic stress test will be included in the study [ Time Frame: CTA studies will be done in an interval of 1 day to 30 days before the invasive studies ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00723281
|United States, California|
|UCSF Medical Center|
|San Francisco, California, United States, 94143|
|Principal Investigator:||Charles B Higgins, MD||UCSF Department of Radiology|