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The Role of Dendritic Cells in Hepatitis C Infection

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ClinicalTrials.gov Identifier: NCT00723242
Recruitment Status : Completed
First Posted : July 28, 2008
Last Update Posted : July 28, 2008
Sponsor:
Collaborator:
Schering-Plough
Information provided by:
University College, London

Brief Summary:
The role of the dendritic cells, the most potent antigen presenting cells, in the establishment of chronic hepatitis C is not established. The study aims to define whether the dendritic cells are affected by the hepatitis C virus and whether that bears an impact on the antiviral immune response they generate. The hypothesis is explored by investigating a group of patients prior to and after the initiation of standard treatment for hepatitis C with pegylated Interferon and Ribavirin.

Condition or disease Intervention/treatment Phase
Chronic Hepatitis C Infection Drug: Viraferon-peg and Rebetol Not Applicable

Study Type : Interventional  (Clinical Trial)
Primary Purpose: Basic Science
Study Start Date : April 2002
Actual Primary Completion Date : December 2004
Actual Study Completion Date : December 2004

Resource links provided by the National Library of Medicine

U.S. FDA Resources




Primary Outcome Measures :
  1. Basic science research (immunology of hepatitis C)in hepatitis c patients receiving established, standard antiviral treatment (pegylated Interferon+Ribavirin)


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Ages Eligible for Study:   18 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • anti-HCV positive
  • HCV RNA positive

Exclusion Criteria:

  • contraindications for antiviral treatment
  • concurrent chronic viral infections

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00723242


Locations
United Kingdom
University College Hospital
London, United Kingdom, NW1 2BU
Sponsors and Collaborators
University College, London
Schering-Plough

Responsible Party: Professor Nikolai V. Naoumov
ClinicalTrials.gov Identifier: NCT00723242     History of Changes
First Posted: July 28, 2008    Key Record Dates
Last Update Posted: July 28, 2008
Last Verified: July 2008

Additional relevant MeSH terms:
Infection
Hepatitis
Hepatitis C
Hepatitis, Chronic
Hepatitis C, Chronic
Liver Diseases
Digestive System Diseases
Hepatitis, Viral, Human
Virus Diseases
Flaviviridae Infections
RNA Virus Infections
Ribavirin
Antimetabolites
Molecular Mechanisms of Pharmacological Action
Antiviral Agents
Anti-Infective Agents