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The Role of Dendritic Cells in Hepatitis C Infection

This study has been completed.
Information provided by:
University College, London Identifier:
First received: July 24, 2008
Last updated: NA
Last verified: July 2008
History: No changes posted
The role of the dendritic cells, the most potent antigen presenting cells, in the establishment of chronic hepatitis C is not established. The study aims to define whether the dendritic cells are affected by the hepatitis C virus and whether that bears an impact on the antiviral immune response they generate. The hypothesis is explored by investigating a group of patients prior to and after the initiation of standard treatment for hepatitis C with pegylated Interferon and Ribavirin.

Condition Intervention
Chronic Hepatitis C Infection Drug: Viraferon-peg and Rebetol

Study Type: Interventional
Study Design: Primary Purpose: Basic Science

Resource links provided by NLM:

Further study details as provided by University College, London:

Primary Outcome Measures:
  • Basic science research (immunology of hepatitis C)in hepatitis c patients receiving established, standard antiviral treatment (pegylated Interferon+Ribavirin)

Study Start Date: April 2002
Study Completion Date: December 2004
Primary Completion Date: December 2004 (Final data collection date for primary outcome measure)

Ages Eligible for Study:   18 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • anti-HCV positive
  • HCV RNA positive

Exclusion Criteria:

  • contraindications for antiviral treatment
  • concurrent chronic viral infections
  Contacts and Locations
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Please refer to this study by its identifier: NCT00723242

United Kingdom
University College Hospital
London, United Kingdom, NW1 2BU
Sponsors and Collaborators
University College, London
  More Information

Responsible Party: Professor Nikolai V. Naoumov Identifier: NCT00723242     History of Changes
Study First Received: July 24, 2008
Last Updated: July 24, 2008

Additional relevant MeSH terms:
Hepatitis C
Hepatitis, Chronic
Hepatitis C, Chronic
Liver Diseases
Digestive System Diseases
Hepatitis, Viral, Human
Virus Diseases
Flaviviridae Infections
RNA Virus Infections
Molecular Mechanisms of Pharmacological Action
Antiviral Agents
Anti-Infective Agents processed this record on June 23, 2017