Evaluation of Vascular Pathology With 3D, Time-Resolved Phase Contrast Magnetic Resonance Imaging (MRI)
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|ClinicalTrials.gov Identifier: NCT00722904|
Recruitment Status : Completed
First Posted : July 28, 2008
Last Update Posted : October 8, 2013
Aortic coarctation is a relatively common cardiovascular condition with high associated mortality if not treated. Even with successful repair, however, close follow up is needed as late complications can result in significant cardiovascular morbidity. MRI, with is ability to provide both anatomic and hemodynamic information, is becoming the imaging option of choice for post-intervention surveillance. Time-resolved, three-dimensional phase contrast magnetic resonance velocity (4D Flow) profiling enables the acquisition of multidirectional blood velocity data. The technique is well suited for evaluation of blood flow patterns in the thoracic aorta. By comparing aortic flow patterns in patients status post coarctation repair with those of healthy volunteers using 4D Flow, this study intends to characterize abnormal flow patterns in these patients with the eventual goal of better understanding and predicting late complications so that preemptive intervention may be taken.
Given the potential use of 4D Flow for evaluation of other types of vascular pathology in the aorta and other vascular regions, we hope to investigate the use of the technique on a limited basis for a broader population of adult patients. Other research groups have had success evaluating peripheral stenoses, as well as intracardiac and intracranial blood flow patterns with 4D Flow.
|Condition or disease|
|Study Type :||Observational|
|Estimated Enrollment :||40 participants|
|Observational Model:||Case Control|
|Official Title:||Evaluation of Vascular Pathology With 3D, Time-Resolved Phase Contrast MRI|
|Study Start Date :||June 2007|
|Primary Completion Date :||July 2009|
|Study Completion Date :||September 2010|
patients undergoing routine post-intervention surveillance of aortic coarctation
- predicting late complications in patients status post coarctation repair so that preemptive intervention may be taken [ Time Frame: For at least three years following the completion of the study, the database of patients will be updated for clinically relevant information ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00722904
|United States, California|
|UCSF Medical Center|
|San Francisco, California, United States, 94143|
|Principal Investigator:||Charles B Higgins, MD||UCSF Department of Radiology|