Lipid-poor Adrenal Masses: Evaluation With Chemical Shift MRI

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00721929
Recruitment Status : Completed
First Posted : July 25, 2008
Last Update Posted : December 6, 2012
Information provided by (Responsible Party):
Gisela Mueller, MD, University of Michigan

Brief Summary:
The purpose of this study is to determine if certain MRI sequences can accurately diagnose adrenal masses of unknown origin.

Condition or disease Intervention/treatment Phase
Adrenal Gland Disease Procedure: MRI Not Applicable

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 16 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Diagnostic
Official Title: Lipid-poor Adrenal Masses: Evaluation With Chemical Shift MRI
Study Start Date : October 2003
Actual Primary Completion Date : July 2010
Actual Study Completion Date : July 2012

Arm Intervention/treatment
Experimental: adrenal mass group Procedure: MRI
Magnetic Resonance Imaging

Primary Outcome Measures :
  1. Diagnosis of either benign or malignant adrenal mass on pathology [ Time Frame: 0-6 months ]
    definitive diagnosis of adrenal mass

Secondary Outcome Measures :
  1. stability of growth of mass on follow up imaging [ Time Frame: 3-24 months ]
    evidence for benign or malignant mass based on assessment of stability or growth

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Patients can participate in this study if they are 18 years of age or older and if they have had a Cat Scan (CT scan) performed with and without contrast media (medication given intravenously to enhance the CT images) or if patients are scheduled to have a CT scan performed and if the reason their physician ordered the CT is because they have an adrenal mass of an unknown type.

Exclusion Criteria:

  • Patients, who have electrically, magnetically or mechanically activated implants such as heart pacemaker, magnetic surgical clips, prostheses or implanted neurological stimulator.
  • Pregnant patients or patients who are lactating.
  • A patient who is claustrophobic and would require sedation to complete the MRI exam.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00721929

United States, Michigan
University of Michigan
Ann Arbor, Michigan, United States, 48109
Sponsors and Collaborators
University of Michigan

Responsible Party: Gisela Mueller, MD, Principal Investigator, University of Michigan Identifier: NCT00721929     History of Changes
Other Study ID Numbers: 2003-0148
First Posted: July 25, 2008    Key Record Dates
Last Update Posted: December 6, 2012
Last Verified: December 2012

Keywords provided by Gisela Mueller, MD, University of Michigan:
adrenal glands, adrenal masses

Additional relevant MeSH terms:
Adrenal Gland Diseases
Endocrine System Diseases
Epinephryl borate
Adrenergic alpha-Agonists
Adrenergic Agonists
Adrenergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs
Adrenergic beta-Agonists
Bronchodilator Agents
Autonomic Agents
Peripheral Nervous System Agents
Anti-Asthmatic Agents
Respiratory System Agents
Vasoconstrictor Agents