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Pharmacokinetics of Carnosine

This study has been completed.
Information provided by:
Tufts University Identifier:
First received: July 22, 2008
Last updated: December 14, 2009
Last verified: December 2009
The absorption kinetics of dietary carnosine (β-alanyl-L-histidine) will be determined in the healthy adults.

Condition Intervention
Oxidative Stress Dietary Supplement: pure carnosine Other: Beef Other: Chicken Other: Chicken broth

Study Type: Interventional
Study Design: Intervention Model: Crossover Assignment
Masking: None (Open Label)
Official Title: Pharmacokinetics of Carnosine

Further study details as provided by Tufts University:

Primary Outcome Measures:
  • Plasma histidine-dipeptide [ Time Frame: 0, 30, 60, 100, 180, 240, & 300 min ]

Enrollment: 4
Study Start Date: April 2007
Study Completion Date: July 2008
Primary Completion Date: October 2007 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1
Carnosine(450 mg)
Dietary Supplement: pure carnosine
one time dose of pure carnosine (450 mg)
Experimental: 2
Beef (150g)
Other: Beef
one time dose, 150 g of beef
Experimental: 3
chicken (150g)
Other: Chicken
One time dose, 150g of chicken breast
Experimental: 4
Chicken broth (obtained from 150 g of chicken breast)
Other: Chicken broth
one time dose of chicken broth obtained from 150g of chicken breast


Ages Eligible for Study:   40 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Healthy adult
  • normal hematological parameters, normal serum albumin, normal liver function, normal kidney function

Exclusion Criteria:

  • History of smoking or alcoholism
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00721708

United States, Massachusetts
Jean Mayer USDA-Human Nutrition Research Center on Aging at Tufts University
Boston, Massachusetts, United States, 02111
Sponsors and Collaborators
Tufts University
Principal Investigator: Kyung-Jin Yeum, Ph.D. Tufts Medical Center
  More Information

Responsible Party: Kyung-Jin Yeum, Scientist, Tufts University Identifier: NCT00721708     History of Changes
Other Study ID Numbers: TMC/TUHS IRB 7737
Study First Received: July 22, 2008
Last Updated: December 14, 2009

Keywords provided by Tufts University:
histidine dipeptides
anserine processed this record on August 21, 2017