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Pharmacokinetics of Carnosine

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ClinicalTrials.gov Identifier: NCT00721708
Recruitment Status : Completed
First Posted : July 24, 2008
Last Update Posted : December 15, 2009
Sponsor:
Information provided by:
Tufts University

Brief Summary:
The absorption kinetics of dietary carnosine (β-alanyl-L-histidine) will be determined in the healthy adults.

Condition or disease Intervention/treatment Phase
Oxidative Stress Dietary Supplement: pure carnosine Other: Beef Other: Chicken Other: Chicken broth Not Applicable

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 4 participants
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Official Title: Pharmacokinetics of Carnosine
Study Start Date : April 2007
Actual Primary Completion Date : October 2007
Actual Study Completion Date : July 2008

Arm Intervention/treatment
Experimental: 1
Carnosine(450 mg)
Dietary Supplement: pure carnosine
one time dose of pure carnosine (450 mg)

Experimental: 2
Beef (150g)
Other: Beef
one time dose, 150 g of beef

Experimental: 3
chicken (150g)
Other: Chicken
One time dose, 150g of chicken breast

Experimental: 4
Chicken broth (obtained from 150 g of chicken breast)
Other: Chicken broth
one time dose of chicken broth obtained from 150g of chicken breast




Primary Outcome Measures :
  1. Plasma histidine-dipeptide [ Time Frame: 0, 30, 60, 100, 180, 240, & 300 min ]


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Ages Eligible for Study:   40 Years to 70 Years   (Adult, Older Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Healthy adult
  • normal hematological parameters, normal serum albumin, normal liver function, normal kidney function

Exclusion Criteria:

  • History of smoking or alcoholism

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00721708


Locations
United States, Massachusetts
Jean Mayer USDA-Human Nutrition Research Center on Aging at Tufts University
Boston, Massachusetts, United States, 02111
Sponsors and Collaborators
Tufts University
Investigators
Principal Investigator: Kyung-Jin Yeum, Ph.D. Tufts Medical Center

Publications of Results:
Responsible Party: Kyung-Jin Yeum, Scientist, Tufts University
ClinicalTrials.gov Identifier: NCT00721708     History of Changes
Other Study ID Numbers: TMC/TUHS IRB 7737
First Posted: July 24, 2008    Key Record Dates
Last Update Posted: December 15, 2009
Last Verified: December 2009

Keywords provided by Tufts University:
histidine dipeptides
carnosine
anserine