This site became the new on June 19th. Learn more.
Show more Menu IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu IMPORTANT: Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu
Give us feedback

Granuloma Annulare Treated With Rifampin, Ofloxacin, and Minocycline Combination Therapy

This study has been completed.
Information provided by:
Henry Ford Health System Identifier:
First received: July 21, 2008
Last updated: NA
Last verified: May 2008
History: No changes posted
Granuloma annulare is a benign, usually self-limiting, cutaneous dermatosis, which typically presents as asymptomatic, flesh-colored or red papules, frequently arranged in an annular pattern on the distal extremities. Although localized granuloma annulare is most commonly observed, a generalized or disseminated form can occur. The etiology of granuloma annulare is unknown, however, multiple inciting factors have been proposed. The purpose of the investigators is to review the outcomes of treatment of granuloma annulare (GA) resistant to standard regimens that resolved after a 3-months treatment course of monthly rifampin, ofloxacin, and minocycline (ROM) therapy, successfully used to treat paucibacillary leprosy, a disease with clinical and histopathologic similarity to GA.

Granuloma Annulare

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Retrospective
Official Title: Granuloma Annulare Treated With Rifampin, Ofloxacin, and Minocycline Combination Therapy

Resource links provided by NLM:

Further study details as provided by Henry Ford Health System:

Enrollment: 6
Study Start Date: May 2008
Study Completion Date: July 2008
Primary Completion Date: May 2008 (Final data collection date for primary outcome measure)
Detailed Description:

We will document the regimen treatment each patient has had and then review the following from the patient's chart to target our specific aims as outlined above.

  1. What previous treatment options have been or/are currently being used?
  2. How long did the patient take the treatment for?
  3. Was the patient able to discontinue or become less dependent on prior treatment?
  4. Was the disease process slowed by the treatment?;
  5. Were there any side effects that the patient experienced with treatment?

Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
The investigators reported 6 cases of resistant GA that resolved after a 3-month treatment course of monthly rifampin, ofloxacin, and minocycline (ROM) therapy. ROM therapy has been successfully used to treat patients with paucibacillary leprosy, which has morphologic and histologic similarities to GA.

Inclusion Criteria:

  • Patients with granuloma annulare who are resistent to the standard treatment.

Exclusion Criteria:

  • Response to the standard treatment of granuloma annulare.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00720980

United States, Michigan
Henry Ford Medical Center
Detroit, Michigan, United States, 48202
Sponsors and Collaborators
Henry Ford Health System
Principal Investigator: Iltefat H Hamzavi, MD Henry Ford Health System
  More Information

Responsible Party: Iltefat H. Hamzavi, MD, Henry Ford Health System Identifier: NCT00720980     History of Changes
Other Study ID Numbers: IRB5074
Study First Received: July 21, 2008
Last Updated: July 21, 2008

Keywords provided by Henry Ford Health System:
granuloma annulare, ROM

Additional relevant MeSH terms:
Granuloma Annulare
Lymphoproliferative Disorders
Lymphatic Diseases
Pathologic Processes
Necrobiotic Disorders
Collagen Diseases
Connective Tissue Diseases
Skin Diseases
Anti-Bacterial Agents
Anti-Infective Agents
Antibiotics, Antitubercular
Antitubercular Agents
Leprostatic Agents
Nucleic Acid Synthesis Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Cytochrome P-450 CYP2B6 Inducers
Cytochrome P-450 Enzyme Inducers
Cytochrome P-450 CYP2C8 Inducers
Cytochrome P-450 CYP2C19 Inducers
Cytochrome P-450 CYP2C9 Inducers
Cytochrome P-450 CYP3A Inducers
Anti-Infective Agents, Urinary
Renal Agents
Topoisomerase II Inhibitors processed this record on August 18, 2017