Granuloma Annulare Treated With Rifampin, Ofloxacin, and Minocycline Combination Therapy

This study has been completed.
Information provided by:
Henry Ford Health System Identifier:
First received: July 21, 2008
Last updated: NA
Last verified: May 2008
History: No changes posted
Granuloma annulare is a benign, usually self-limiting, cutaneous dermatosis, which typically presents as asymptomatic, flesh-colored or red papules, frequently arranged in an annular pattern on the distal extremities. Although localized granuloma annulare is most commonly observed, a generalized or disseminated form can occur. The etiology of granuloma annulare is unknown, however, multiple inciting factors have been proposed. The purpose of the investigators is to review the outcomes of treatment of granuloma annulare (GA) resistant to standard regimens that resolved after a 3-months treatment course of monthly rifampin, ofloxacin, and minocycline (ROM) therapy, successfully used to treat paucibacillary leprosy, a disease with clinical and histopathologic similarity to GA.

Granuloma Annulare

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Retrospective
Official Title: Granuloma Annulare Treated With Rifampin, Ofloxacin, and Minocycline Combination Therapy

Resource links provided by NLM:

Further study details as provided by Henry Ford Health System:

Enrollment: 6
Study Start Date: May 2008
Study Completion Date: July 2008
Primary Completion Date: May 2008 (Final data collection date for primary outcome measure)
Detailed Description:

We will document the regimen treatment each patient has had and then review the following from the patient's chart to target our specific aims as outlined above.

  1. What previous treatment options have been or/are currently being used?
  2. How long did the patient take the treatment for?
  3. Was the patient able to discontinue or become less dependent on prior treatment?
  4. Was the disease process slowed by the treatment?;
  5. Were there any side effects that the patient experienced with treatment?

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
The investigators reported 6 cases of resistant GA that resolved after a 3-month treatment course of monthly rifampin, ofloxacin, and minocycline (ROM) therapy. ROM therapy has been successfully used to treat patients with paucibacillary leprosy, which has morphologic and histologic similarities to GA.

Inclusion Criteria:

  • Patients with granuloma annulare who are resistent to the standard treatment.

Exclusion Criteria:

  • Response to the standard treatment of granuloma annulare.
  Contacts and Locations
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Please refer to this study by its identifier: NCT00720980

United States, Michigan
Henry Ford Medical Center
Detroit, Michigan, United States, 48202
Sponsors and Collaborators
Henry Ford Health System
Principal Investigator: Iltefat H Hamzavi, MD Henry Ford Health System
  More Information

Responsible Party: Iltefat H. Hamzavi, MD, Henry Ford Health System Identifier: NCT00720980     History of Changes
Other Study ID Numbers: IRB5074
Study First Received: July 21, 2008
Last Updated: July 21, 2008
Health Authority: United States: Institutional Review Board

Keywords provided by Henry Ford Health System:
granuloma annulare, ROM

Additional relevant MeSH terms:
Granuloma Annulare
Collagen Diseases
Connective Tissue Diseases
Lymphatic Diseases
Lymphoproliferative Disorders
Necrobiotic Disorders
Pathologic Processes
Skin Diseases processed this record on December 01, 2015