Try our beta test site
IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more...

Glucose Metabolism and Sleep in People With Family History of Type 2 Diabetes.

This study has been completed.
National Heart, Lung, and Blood Institute (NHLBI)
Information provided by (Responsible Party):
University of Chicago Identifier:
First received: July 21, 2008
Last updated: September 4, 2013
Last verified: September 2013
The use of sugar and starch-like foods for energy (carbohydrate metabolism) changes when people sleep. However, it is still not known if differences in the amount of nighttime sleep have an effect on the carbohydrate metabolism of people who have a relative with type 2 diabetes (parent, sibling, or grandparent). This study is being done to test the hypothesis that individual differences in habitual sleep duration may be related to differences in the carbohydrate metabolism of people who have a history of type 2 diabetes in their family.

Insulin Resistance
Type 2 Diabetes

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Sleep, Energy Metabolism and Diabetes Risk.

Further study details as provided by University of Chicago:

Primary Outcome Measures:
  • Total body insulin sensitivity [ Time Frame: at the end of a 4-hour hyperinsulinemic clamp ]

Secondary Outcome Measures:
  • First and second phase insulin secretion [ Time Frame: during a 3-hour hyperglycemic clamp ]
  • Endogenous glucose production [ Time Frame: before and during a 4-hour hyperinsulinemic clamp ]
  • Glycerol turnover and free fatty acid concentration [ Time Frame: before and during a 4-hour hyperinsulinemic clamp ]

Enrollment: 20
Study Start Date: July 2008
Study Completion Date: March 2012
Primary Completion Date: March 2012 (Final data collection date for primary outcome measure)
Reduced sleep
Habitual sleep duration of less than 6 hours per night on most days of the week and total sleep of less than 43 hours per week.
Reference sleep
Habitual sleep duration between 7 and 8.5 hours per night on most days of the week and total sleep of at least 53 hours per week.

Detailed Description:
On two consecutive inpatient days, the participants in this study will undergo two different tests. The first test will determine how much insulin can their body produce in response to an intravenous glucose infusion over a period of several hours. The second test will determine how effective is the action of the sugar-processing hormone, insulin, in their body when it is infused intravenously together with glucose over a period of several hours.

Ages Eligible for Study:   21 Years to 40 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Healthy non-obese community-living men and women with a parent, sibling or grandparent who has type 2 diabetes

Inclusion Criteria:

  • regular sleep habits
  • BMI 20 to 27 kg/m2
  • at least one parent, sibling or grandparent with type 2 diabetes
  • no regular exercise habits

Exclusion Criteria:

  • active smoker
  • night or shift work
  • have highly variable sleep habits
  • have a hormonal disorder
  • have a sleep disorder
  • have an active medical problem
  • women only: use of birth control pills
  • women only: irregular menstrual periods or pregnancy
  • use of medications/compounds that can disrupt sleep
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00720889

United States, Illinois
University of Chicago
Chicago, Illinois, United States, 60637
Sponsors and Collaborators
University of Chicago
National Heart, Lung, and Blood Institute (NHLBI)
Principal Investigator: Plamen D Penev, MD, PhD University of Chicago
  More Information

Responsible Party: University of Chicago Identifier: NCT00720889     History of Changes
Other Study ID Numbers: 16079A-S2
R01HL089637 ( US NIH Grant/Contract Award Number )
Study First Received: July 21, 2008
Last Updated: September 4, 2013

Keywords provided by University of Chicago:
short sleep duration
glucose clamp technique
insulin secretion
insulin action
lipid turnover
free fatty acids

Additional relevant MeSH terms:
Diabetes Mellitus
Diabetes Mellitus, Type 2
Insulin Resistance
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases
Hyperinsulinism processed this record on April 26, 2017