Pulsatile and Steady State Hemodynamics in Diastolic Heart Failure

This study has been completed.
Information provided by:
Klinikum Wels-Grieskirchen
ClinicalTrials.gov Identifier:
First received: July 18, 2008
Last updated: July 15, 2011
Last verified: July 2011
Over the past few years, there has been a growing appreciation that a large number of patients with heart failure have a relatively normal (or preserved) ejection fraction (NFNEF). Epidemiologically, HFNEF is most prevalent among elderly women, most of whom have hypertension, diabetes, or both and often coronary artery disease (CAD). Increased arterial stiffness and/or wave reflections have been described in the same patient groups. Therefore, the investigators speculate that pulsatile hemodynamics, representing arterial stiffness and/or arterial wave reflections, 1) may be altered in HFNEF patients, 2) this may contribute to pathophysiology of HFNEF, and 3) this may be used for the diagnosis of the syndrome.

Diastolic Heart Failure

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Diagnostic Value of Measures of Pulsatile Versus Steady State Hemodynamics in Diastolic Heart Failure

Resource links provided by NLM:

Further study details as provided by Klinikum Wels-Grieskirchen:

Enrollment: 362
Study Start Date: April 2008
Study Completion Date: July 2011
Patients with diastolic heart failure
Patients without diastolic heart failure


Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Patients undergoing invasive assessment for exertional dyspnea

Inclusion Criteria:

  • exertional dyspnea
  • undergoing heart catheterization for diagnosis or exclusion of coronary artery disease
  • normal EF (> 50%)

Exclusion Criteria:

  • atrial fibrillation
  • more than mild valvular heart disease
  • pericardial disease
  • no informed consent
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00720525

Cardiology Department, Klinikum Wels-Grieskirchen
Wels, Austria, 4600
Sponsors and Collaborators
Klinikum Wels-Grieskirchen
Principal Investigator: Thomas Weber, MD Cardiology Department, Klinikum Wels-Grieskirchen, Austria
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Dr Thomas Weber, Cardiology Department, Klinikum Wels-Grieskirchen, Austria
ClinicalTrials.gov Identifier: NCT00720525     History of Changes
Other Study ID Numbers: EK 248 
Study First Received: July 18, 2008
Last Updated: July 15, 2011
Health Authority: Austria: Ethikkommission

Keywords provided by Klinikum Wels-Grieskirchen:
arterial stiffness
arterial wave reflections
diastolic heart failure

Additional relevant MeSH terms:
Heart Failure
Heart Failure, Diastolic
Cardiovascular Diseases
Heart Diseases

ClinicalTrials.gov processed this record on May 26, 2016