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Pulsatile and Steady State Hemodynamics in Diastolic Heart Failure

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00720525
First Posted: July 22, 2008
Last Update Posted: July 18, 2011
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Klinikum Wels-Grieskirchen
  Purpose
Over the past few years, there has been a growing appreciation that a large number of patients with heart failure have a relatively normal (or preserved) ejection fraction (NFNEF). Epidemiologically, HFNEF is most prevalent among elderly women, most of whom have hypertension, diabetes, or both and often coronary artery disease (CAD). Increased arterial stiffness and/or wave reflections have been described in the same patient groups. Therefore, the investigators speculate that pulsatile hemodynamics, representing arterial stiffness and/or arterial wave reflections, 1) may be altered in HFNEF patients, 2) this may contribute to pathophysiology of HFNEF, and 3) this may be used for the diagnosis of the syndrome.

Condition
Diastolic Heart Failure

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Diagnostic Value of Measures of Pulsatile Versus Steady State Hemodynamics in Diastolic Heart Failure

Resource links provided by NLM:


Further study details as provided by Klinikum Wels-Grieskirchen:

Enrollment: 362
Study Start Date: April 2008
Study Completion Date: July 2011
Groups/Cohorts
1
Patients with diastolic heart failure
2
Patients without diastolic heart failure

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Patients undergoing invasive assessment for exertional dyspnea
Criteria

Inclusion Criteria:

  • exertional dyspnea
  • undergoing heart catheterization for diagnosis or exclusion of coronary artery disease
  • normal EF (> 50%)

Exclusion Criteria:

  • atrial fibrillation
  • more than mild valvular heart disease
  • pericardial disease
  • no informed consent
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00720525


Locations
Austria
Cardiology Department, Klinikum Wels-Grieskirchen
Wels, Austria, 4600
Sponsors and Collaborators
Klinikum Wels-Grieskirchen
Investigators
Principal Investigator: Thomas Weber, MD Cardiology Department, Klinikum Wels-Grieskirchen, Austria
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Dr Thomas Weber, Cardiology Department, Klinikum Wels-Grieskirchen, Austria
ClinicalTrials.gov Identifier: NCT00720525     History of Changes
Other Study ID Numbers: EK 248
First Submitted: July 18, 2008
First Posted: July 22, 2008
Last Update Posted: July 18, 2011
Last Verified: July 2011

Keywords provided by Klinikum Wels-Grieskirchen:
arterial stiffness
arterial wave reflections
diastolic heart failure

Additional relevant MeSH terms:
Heart Failure
Heart Failure, Diastolic
Heart Diseases
Cardiovascular Diseases