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Pain Relief of Metoprolol Versus Metoprolol Plus Morphine in Acute Chest Pain

This study has been completed.
Information provided by:
Sahlgrenska University Hospital, Sweden Identifier:
First received: July 16, 2008
Last updated: NA
Last verified: August 2002
History: No changes posted
The primary aim was to evaluate the relief of chest pain during the first 30 minutes among patients who received metoprolol alone as compared with metoprolol plus morphine

Condition Intervention Phase
Acute Coronary Syndromes
Drug: Metoprolol
Drug: metoprolol plus morphine
Phase 4

Study Type: Interventional

Resource links provided by NLM:

Further study details as provided by Sahlgrenska University Hospital, Sweden:

Arms Assigned Interventions
Active Comparator: A
Drug: Metoprolol
Active Comparator: B
B=metoprolol plus morphine
Drug: metoprolol plus morphine


Ages Eligible for Study:   Child, Adult, Senior
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Acute chest pain
  • ECG-signs indicating myocardial ischemia

Exclusion Criteria:

  • Heart rate < 60 beats/min
  • Systolic blood pressure < 110 mmHg
  • High degree AV-block
  • Signs of obstructive pulmonary disease
  • Signs of pulmonary oedema
  • Unwillingness
  • Participation in other studies
  • Long delay between arrival of ambulance and randomisation
  Contacts and Locations
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Please refer to this study by its identifier: NCT00718406

Medical Institution, Dept of Molecular and Clinical Medicine, Sahlgrenska University Hospital
Göteborg, Sweden, SE-413 45
Sponsors and Collaborators
Sahlgrenska University Hospital, Sweden
  More Information Identifier: NCT00718406     History of Changes
Other Study ID Numbers: S203-02 
Study First Received: July 16, 2008
Last Updated: July 16, 2008
Health Authority: Sweden: Regional Ethical Review Board

Keywords provided by Sahlgrenska University Hospital, Sweden:
Acute coronary syndrome
Chest pain
Prehospital phase

Additional relevant MeSH terms:
Acute Coronary Syndrome
Chest Pain
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Vascular Diseases
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms
Anti-Arrhythmia Agents
Antihypertensive Agents
Autonomic Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Adrenergic beta-1 Receptor Antagonists
Adrenergic beta-Antagonists
Adrenergic Antagonists
Adrenergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Analgesics, Opioid
Central Nervous System Depressants
Sensory System Agents processed this record on October 27, 2016