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Pain Relief of Metoprolol Versus Metoprolol Plus Morphine in Acute Chest Pain

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ClinicalTrials.gov Identifier: NCT00718406
Recruitment Status : Completed
First Posted : July 18, 2008
Last Update Posted : July 18, 2008
Sponsor:
Collaborator:
AstraZeneca
Information provided by:
Sahlgrenska University Hospital, Sweden

Brief Summary:
The primary aim was to evaluate the relief of chest pain during the first 30 minutes among patients who received metoprolol alone as compared with metoprolol plus morphine

Condition or disease Intervention/treatment Phase
Acute Coronary Syndromes Drug: Metoprolol Drug: metoprolol plus morphine Phase 4

Study Type : Interventional  (Clinical Trial)

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Chest Pain

Arm Intervention/treatment
Active Comparator: A
A=metoprolol
Drug: Metoprolol
Active Comparator: B
B=metoprolol plus morphine
Drug: metoprolol plus morphine




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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Acute chest pain
  • ECG-signs indicating myocardial ischemia

Exclusion Criteria:

  • Heart rate < 60 beats/min
  • Systolic blood pressure < 110 mmHg
  • High degree AV-block
  • Signs of obstructive pulmonary disease
  • Signs of pulmonary oedema
  • Unwillingness
  • Participation in other studies
  • Long delay between arrival of ambulance and randomisation

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00718406


Locations
Sweden
Medical Institution, Dept of Molecular and Clinical Medicine, Sahlgrenska University Hospital
Göteborg, Sweden, SE-413 45
Sponsors and Collaborators
Sahlgrenska University Hospital, Sweden
AstraZeneca

ClinicalTrials.gov Identifier: NCT00718406     History of Changes
Other Study ID Numbers: S203-02
First Posted: July 18, 2008    Key Record Dates
Last Update Posted: July 18, 2008
Last Verified: August 2002

Keywords provided by Sahlgrenska University Hospital, Sweden:
Acute coronary syndrome
Chest pain
Betablockers
Morphine
Prehospital phase

Additional relevant MeSH terms:
Acute Coronary Syndrome
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Vascular Diseases
Morphine
Metoprolol
Analgesics, Opioid
Narcotics
Central Nervous System Depressants
Physiological Effects of Drugs
Analgesics
Sensory System Agents
Peripheral Nervous System Agents
Anti-Arrhythmia Agents
Antihypertensive Agents
Sympatholytics
Autonomic Agents
Adrenergic beta-1 Receptor Antagonists
Adrenergic beta-Antagonists
Adrenergic Antagonists
Adrenergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action