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Pain Relief of Metoprolol Versus Metoprolol Plus Morphine in Acute Chest Pain

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00718406
First Posted: July 18, 2008
Last Update Posted: July 18, 2008
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
AstraZeneca
Information provided by:
Sahlgrenska University Hospital, Sweden
  Purpose
The primary aim was to evaluate the relief of chest pain during the first 30 minutes among patients who received metoprolol alone as compared with metoprolol plus morphine

Condition Intervention Phase
Acute Coronary Syndromes Drug: Metoprolol Drug: metoprolol plus morphine Phase 4

Study Type: Interventional

Resource links provided by NLM:


Further study details as provided by Sahlgrenska University Hospital, Sweden:

Arms Assigned Interventions
Active Comparator: A
A=metoprolol
Drug: Metoprolol
Active Comparator: B
B=metoprolol plus morphine
Drug: metoprolol plus morphine

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Acute chest pain
  • ECG-signs indicating myocardial ischemia

Exclusion Criteria:

  • Heart rate < 60 beats/min
  • Systolic blood pressure < 110 mmHg
  • High degree AV-block
  • Signs of obstructive pulmonary disease
  • Signs of pulmonary oedema
  • Unwillingness
  • Participation in other studies
  • Long delay between arrival of ambulance and randomisation
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00718406


Locations
Sweden
Medical Institution, Dept of Molecular and Clinical Medicine, Sahlgrenska University Hospital
Göteborg, Sweden, SE-413 45
Sponsors and Collaborators
Sahlgrenska University Hospital, Sweden
AstraZeneca
  More Information

ClinicalTrials.gov Identifier: NCT00718406     History of Changes
Other Study ID Numbers: S203-02
First Submitted: July 16, 2008
First Posted: July 18, 2008
Last Update Posted: July 18, 2008
Last Verified: August 2002

Keywords provided by Sahlgrenska University Hospital, Sweden:
Acute coronary syndrome
Chest pain
Betablockers
Morphine
Prehospital phase

Additional relevant MeSH terms:
Acute Coronary Syndrome
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Vascular Diseases
Morphine
Metoprolol
Analgesics, Opioid
Narcotics
Central Nervous System Depressants
Physiological Effects of Drugs
Analgesics
Sensory System Agents
Peripheral Nervous System Agents
Anti-Arrhythmia Agents
Antihypertensive Agents
Sympatholytics
Autonomic Agents
Adrenergic beta-1 Receptor Antagonists
Adrenergic beta-Antagonists
Adrenergic Antagonists
Adrenergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action