Pain Relief of Metoprolol Versus Metoprolol Plus Morphine in Acute Chest Pain

This study has been completed.
Information provided by:
Sahlgrenska University Hospital, Sweden Identifier:
First received: July 16, 2008
Last updated: NA
Last verified: August 2002
History: No changes posted
The primary aim was to evaluate the relief of chest pain during the first 30 minutes among patients who received metoprolol alone as compared with metoprolol plus morphine

Condition Intervention Phase
Acute Coronary Syndromes
Drug: Metoprolol
Drug: metoprolol plus morphine
Phase 4

Study Type: Interventional

Resource links provided by NLM:

Further study details as provided by Sahlgrenska University Hospital, Sweden:

Arms Assigned Interventions
Active Comparator: A
Drug: Metoprolol
Active Comparator: B
B=metoprolol plus morphine
Drug: metoprolol plus morphine


Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Acute chest pain
  • ECG-signs indicating myocardial ischemia

Exclusion Criteria:

  • Heart rate < 60 beats/min
  • Systolic blood pressure < 110 mmHg
  • High degree AV-block
  • Signs of obstructive pulmonary disease
  • Signs of pulmonary oedema
  • Unwillingness
  • Participation in other studies
  • Long delay between arrival of ambulance and randomisation
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00718406

Medical Institution, Dept of Molecular and Clinical Medicine, Sahlgrenska University Hospital
Göteborg, Sweden, SE-413 45
Sponsors and Collaborators
Sahlgrenska University Hospital, Sweden
  More Information Identifier: NCT00718406     History of Changes
Other Study ID Numbers: S203-02 
Study First Received: July 16, 2008
Last Updated: July 16, 2008
Health Authority: Sweden: Regional Ethical Review Board

Keywords provided by Sahlgrenska University Hospital, Sweden:
Acute coronary syndrome
Chest pain
Prehospital phase

Additional relevant MeSH terms:
Acute Coronary Syndrome
Angina Pectoris
Cardiovascular Diseases
Chest Pain
Heart Diseases
Myocardial Ischemia
Signs and Symptoms
Vascular Diseases
Metoprolol succinate
Adrenergic Agents
Adrenergic Antagonists
Adrenergic beta-1 Receptor Antagonists
Adrenergic beta-Antagonists
Analgesics, Opioid
Anti-Arrhythmia Agents
Antihypertensive Agents
Autonomic Agents
Cardiovascular Agents
Central Nervous System Agents
Central Nervous System Depressants
Molecular Mechanisms of Pharmacological Action
Neurotransmitter Agents
Peripheral Nervous System Agents
Pharmacologic Actions
Physiological Effects of Drugs processed this record on May 05, 2016