A Retrospective Clinical Records Review of Patients Diagnosed With Gastrointestinal Stromal Tumour at Two Tertiary Institutes in Singapore
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|ClinicalTrials.gov Identifier: NCT00718211|
Recruitment Status : Unknown
Verified July 2008 by National University Hospital, Singapore.
Recruitment status was: Recruiting
First Posted : July 18, 2008
Last Update Posted : July 21, 2008
|Condition or disease|
|Gastrointestinal Stromal Tumors|
A retrospective clinical records review of patients diagnosed with gastrointestinal stromal tumour (GIST) in the two tertiary centres in Singapore i.e. Singapore General Hospital and National University Hospital.
Gastrointestinal tumours are the most common soft-tissue tumours of the gastrointestinal tracts. Remarkable progress has been made during the last several years in the diagnosis and treatment of GIST. Understanding of the molecular pathogenesis of GIST which is linked to deregulated KIT tyrosine-kinase activity has improved diagnosis, such that GIST is now more frequently and specifically identified. More importantly, systemic tyrosine kinase inhibitor, imatinib, has been used successfully in the treatment of GIST patients with advanced or unresectable disease.
GIST has been reviewed in the Western literature but there is a lack of Asian data. The review will help us to better understand the disease in our population.Furthermore we will also examine several unresolved issues in the Western literature by looking into our local data. These include required duration of imatinib therapy, role of imatinib in the adjuvant setting (application of chemotherapy after macroscopically complete removal of tumour) and role of combination therapies.
The medical records of all patients diagnosed with the disease at the two centres will be reviewed.
Analysis of the results aims to:
- to compare the characteristics of the GIST (epidemiology, site, morphology, immunohistochemistry profile) in our centres compared to the well-published literature.
- to compare the treatment regimen and results of our centres compared to others
- to review the role of chemotherapy in the adjuvant settings in the centres.
|Study Type :||Observational|
|Official Title:||A Retrospective Clinical Records Review of Patients Diagnosed With Gastrointestinal Stromal Tumour at Two Tertiary Institutes in Singapore.|
|Study Start Date :||May 2006|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00718211
|Contact: Ross Andrew Soo, MBBS||65-6772-4624||Ross_Soo@nuh.com.sg|
|National University Hospital||Recruiting|
|Contact: Ross Andrew Soo, MBBS 65-6772-4624 Ross_Soo@nuh.com.sg|
|Principal Investigator: Ross Andrew Soo, MBBS|
|Principal Investigator:||Ross Andrew Soo, MBBS||National University Hospital, Singapore|