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A Retrospective Clinical Records Review of Patients Diagnosed With Gastrointestinal Stromal Tumour at Two Tertiary Institutes in Singapore

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified July 2008 by National University Hospital, Singapore.
Recruitment status was:  Recruiting
Information provided by:
National University Hospital, Singapore Identifier:
First received: July 15, 2008
Last updated: July 18, 2008
Last verified: July 2008
To review the characteristics and treatment of gastrointestinal tumours at the two tertiary centres in Singapore

Gastrointestinal Stromal Tumors

Study Type: Observational
Official Title: A Retrospective Clinical Records Review of Patients Diagnosed With Gastrointestinal Stromal Tumour at Two Tertiary Institutes in Singapore.

Resource links provided by NLM:

Further study details as provided by National University Hospital, Singapore:

Study Start Date: May 2006
Detailed Description:

A retrospective clinical records review of patients diagnosed with gastrointestinal stromal tumour (GIST) in the two tertiary centres in Singapore i.e. Singapore General Hospital and National University Hospital.

Gastrointestinal tumours are the most common soft-tissue tumours of the gastrointestinal tracts. Remarkable progress has been made during the last several years in the diagnosis and treatment of GIST. Understanding of the molecular pathogenesis of GIST which is linked to deregulated KIT tyrosine-kinase activity has improved diagnosis, such that GIST is now more frequently and specifically identified. More importantly, systemic tyrosine kinase inhibitor, imatinib, has been used successfully in the treatment of GIST patients with advanced or unresectable disease.

GIST has been reviewed in the Western literature but there is a lack of Asian data. The review will help us to better understand the disease in our population.Furthermore we will also examine several unresolved issues in the Western literature by looking into our local data. These include required duration of imatinib therapy, role of imatinib in the adjuvant setting (application of chemotherapy after macroscopically complete removal of tumour) and role of combination therapies.

The medical records of all patients diagnosed with the disease at the two centres will be reviewed.

Analysis of the results aims to:

  1. to compare the characteristics of the GIST (epidemiology, site, morphology, immunohistochemistry profile) in our centres compared to the well-published literature.
  2. to compare the treatment regimen and results of our centres compared to others
  3. to review the role of chemotherapy in the adjuvant settings in the centres.

Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

To review medical records of all patients diagnosed with the disease at the two specified centres.

The medical records will be obtained through both paper and electronic medical systems.

All data will be contained in a password secured database and will be securely located behind institutional firewalls.


Inclusion Criteria:

  • Patients diagnosed with Gastrointestinal stromal tumor.
  Contacts and Locations
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Please refer to this study by its identifier: NCT00718211

Contact: Ross Andrew Soo, MBBS 65-6772-4624

National University Hospital Recruiting
Singapore, Singapore
Contact: Ross Andrew Soo, MBBS    65-6772-4624   
Principal Investigator: Ross Andrew Soo, MBBS         
Sponsors and Collaborators
National University Hospital, Singapore
Principal Investigator: Ross Andrew Soo, MBBS National University Hospital, Singapore
  More Information Identifier: NCT00718211     History of Changes
Other Study ID Numbers: GA01/12/06
Study First Received: July 15, 2008
Last Updated: July 18, 2008

Additional relevant MeSH terms:
Gastrointestinal Stromal Tumors
Neoplasms, Connective Tissue
Neoplasms, Connective and Soft Tissue
Neoplasms by Histologic Type
Gastrointestinal Neoplasms
Digestive System Neoplasms
Digestive System Diseases
Gastrointestinal Diseases processed this record on May 25, 2017