Association of Multiple Genetic Polymorphisms With Clozapine-Associated Metabolic Change in Schizophrenia
|ClinicalTrials.gov Identifier: NCT00717509|
Recruitment Status : Unknown
Verified June 2009 by Seoul National Hospital.
Recruitment status was: Recruiting
First Posted : July 17, 2008
Last Update Posted : June 12, 2009
|Condition or disease|
|Schizophrenia Metabolic Syndrome Genetic Polymorphism|
The use of antipsychotics, especially clozapine and olanzapine is associated with metabolic side effects, which put patients with schizophrenia at risk for cardiovascular morbidity or diabetes.
The prevalence of the metabolic syndrome was 53.8% of patients who taking clozapine. The high interindividual variability in antipsychotic-induced metabolic abnormalities suggests that genetic makeup is a possible determinant.
The genotypes of the multiple gene such as HTR2C, LEP, adrenergic receptor,PPAR,GNB3 are suggested to have associations with the metabolic side effects (weight,glucose,lipid,BP,metabolic syndrome) in patients using antipsychotics.
We are going to investigate whether those multiple genetic polymorphisms are associated with the metabolic side effects in patients taking clozapine.
|Study Type :||Observational|
|Estimated Enrollment :||150 participants|
|Official Title:||Cross-Sectional Study of the Association Between Multiple Genetic Polymorphisms and the Metabolic Side Effects in Patients With Schizophrenia Taking Clozapine More Than 1 Year|
|Study Start Date :||October 2007|
|Primary Completion Date :||January 2009|
|Estimated Study Completion Date :||October 2009|
U.S. FDA Resources
- The associations between multiplegenetic polymorphisms (HTR2C,leptin,adrenergic receptor,PPAR,GNB3) and the metabolic side effects (weight,glucose,lipid,BP,metabolic syndrome) [ Time Frame: more than 1 year after starting clozapine ]
Biospecimen Retention: Samples With DNA
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00717509
|Contact: Shi Hyun Kang, M.D.||email@example.com|
|Korea, Republic of|
|Seoul National Hospital||Recruiting|
|Seoul, Korea, Republic of, 139-757|
|Contact: Shi Hyun Kang, M.D. 82-2-2204-0326 firstname.lastname@example.org|
|Study Director:||Shi Hyun Kang, M.D.||Seoul National Hospital|