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Trial record 11 of 99 for:    Oleic Acids

Effect of Oleic Acid on Inflammation Markers and Blood Lipid Metabolites: A Randomised, Double-Blind, Crossover Study

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ClinicalTrials.gov Identifier: NCT00715312
Recruitment Status : Completed
First Posted : July 15, 2008
Last Update Posted : July 15, 2008
Sponsor:
Information provided by:
Malaysia Palm Oil Board

Brief Summary:

Rationale: The effect of positional distribution of dietary fatty acids on markers of inflammation and blood lipids metabolites on diets containing fatty acids such as oleic acid that are associated with reduced risk of cardiovascular disease is not widely studied.

Hypothesis: There would be difference detected in the concentrations of markers of inflammation and blood lipid metabolites in human volunteers fed controlled diets.

Study design: A randomized, double-blind, crossover clinical trial that involves 41 healthy volunteers. The volunteers will be selected based on inclusion and exclusion criteria. They will consume controlled diets for 5 weeks that provides 15% of energy from protein, 30% of energy from fat, and 55% of energy from carbohydrates. Volunteers will be assigned to each test diets which is cooked with novel olein, palm stearin or partially hydrogenated soybean oil in random order until all three diets has consumed by each person.

Main study parameters: LDL-cholesterol


Condition or disease Intervention/treatment Phase
Inflammation Other: Novel Olein Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 43 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Prevention
Official Title: Effect of Oleic Acid on Inflammation Markers and Blood Lipid Metabolites: A Randomised, Double-Blind, Crossover Study.
Study Start Date : February 2008
Actual Primary Completion Date : June 2008
Actual Study Completion Date : June 2008

Arm Intervention/treatment
Experimental: A Other: Novel Olein
A total of 70g of test oil is incorporated into cooked meal which accounts for 30-35% of calorie intake

Other: Novel Olein
A total of 70g of test oil is incorporated into cooked meal which provides 30-35% of calorie




Primary Outcome Measures :
  1. LDL-cholesterol [ Time Frame: 5 weeks ]

Secondary Outcome Measures :
  1. C-reactive protein [ Time Frame: 5 weeks ]


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Ages Eligible for Study:   18 Years to 75 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Healthy and free from any disease and absence of family history for arteriosclerosis or hypertension
  • Not on any medication or supplements or weight loss program
  • Non smokers and alcoholics

Exclusion Criteria:

  • Having some health-related problems e.g fever, flu, allergy, chronic diseases
  • On some treatment or medication
  • Smokers and alcoholics

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00715312


Locations
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Malaysia
Malaysia Palm Oil Board
Kajang, Selangor, Malaysia, 50720
Sponsors and Collaborators
Malaysia Palm Oil Board
Investigators
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Principal Investigator: Teng Kim Tiu Malaysia Palm Oil Board

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Responsible Party: Teng Kim Tiu/Ms, Malaysian Palm Oil Board (MPOB)
ClinicalTrials.gov Identifier: NCT00715312     History of Changes
Other Study ID Numbers: 625.9
First Posted: July 15, 2008    Key Record Dates
Last Update Posted: July 15, 2008
Last Verified: July 2008

Keywords provided by Malaysia Palm Oil Board:
Inflammation
LDL
Oleic acid
Palmitic acid
trans fatty acid
C-reactive protein

Additional relevant MeSH terms:
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Inflammation
Pathologic Processes