Effect of Oleic Acid on Inflammation Markers and Blood Lipid Metabolites: A Randomised, Double-Blind, Crossover Study
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|ClinicalTrials.gov Identifier: NCT00715312|
Recruitment Status : Completed
First Posted : July 15, 2008
Last Update Posted : July 15, 2008
Rationale: The effect of positional distribution of dietary fatty acids on markers of inflammation and blood lipids metabolites on diets containing fatty acids such as oleic acid that are associated with reduced risk of cardiovascular disease is not widely studied.
Hypothesis: There would be difference detected in the concentrations of markers of inflammation and blood lipid metabolites in human volunteers fed controlled diets.
Study design: A randomized, double-blind, crossover clinical trial that involves 41 healthy volunteers. The volunteers will be selected based on inclusion and exclusion criteria. They will consume controlled diets for 5 weeks that provides 15% of energy from protein, 30% of energy from fat, and 55% of energy from carbohydrates. Volunteers will be assigned to each test diets which is cooked with novel olein, palm stearin or partially hydrogenated soybean oil in random order until all three diets has consumed by each person.
Main study parameters: LDL-cholesterol
|Condition or disease||Intervention/treatment||Phase|
|Inflammation||Other: Novel Olein||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||43 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||Double (Participant, Investigator)|
|Official Title:||Effect of Oleic Acid on Inflammation Markers and Blood Lipid Metabolites: A Randomised, Double-Blind, Crossover Study.|
|Study Start Date :||February 2008|
|Actual Primary Completion Date :||June 2008|
|Actual Study Completion Date :||June 2008|
Other: Novel Olein
A total of 70g of test oil is incorporated into cooked meal which accounts for 30-35% of calorie intake
Other: Novel Olein
A total of 70g of test oil is incorporated into cooked meal which provides 30-35% of calorie
- LDL-cholesterol [ Time Frame: 5 weeks ]
- C-reactive protein [ Time Frame: 5 weeks ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00715312
|Malaysia Palm Oil Board|
|Kajang, Selangor, Malaysia, 50720|
|Principal Investigator:||Teng Kim Tiu||Malaysia Palm Oil Board|