Heat Stress and Volume Administration

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00714766
Recruitment Status : Completed
First Posted : July 14, 2008
Last Update Posted : February 16, 2009
Information provided by:
Rigshospitalet, Denmark

Brief Summary:
Heat stress reduces the central blood volume and causes orthostatic intolerance. The hypothesis is that infusion of volume may reduce effects of orthostatic stress during heat stress.

Condition or disease Intervention/treatment Phase
Syncope Procedure: Intravascular volume administration Not Applicable

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 10 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Heat Stress and Volume Administration
Study Start Date : July 2008
Actual Primary Completion Date : August 2008
Actual Study Completion Date : August 2008

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Arm Intervention/treatment
Experimental: A Procedure: Intravascular volume administration
Infusion of colloid to reestablish CVP under heat stress

Primary Outcome Measures :
  1. Cardiac filling pressure in relation to cardiac SV [ Time Frame: with varying degress of lower body negative pressures ]

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Age > 18 < 40

Exclusion Criteria:

  • Abnormal medical history

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00714766

Dept of anesthesiology 2041
Copenhagen, Denmark, 2100
Sponsors and Collaborators
Rigshospitalet, Denmark
Study Director: Niels Secher, MD, PhD Rigshospitalet, Denmark

Responsible Party: Niels Secher, Professor, Righospitale Identifier: NCT00714766     History of Changes
Other Study ID Numbers: Heat stress RH08
First Posted: July 14, 2008    Key Record Dates
Last Update Posted: February 16, 2009
Last Verified: February 2009

Additional relevant MeSH terms:
Heat Stress Disorders
Consciousness Disorders
Neurobehavioral Manifestations
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms
Wounds and Injuries