Establishing Normal Values for Neuropsychological Testing in HIV-negative Thais
The purpose of this study is to establish normal values for neuropsychological testing in HIV negative Thais stratified by age (1 decade) and education (no certificate or primary school certificate, less than high school certificate or vocational certificate, high school certificate or higher vocational certificate or diploma, Bachelor degree or higher.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
- To establish normal values for neuropsychological testing in HIV negative Thais stratified by age (1 decade) and education [ Time Frame: July 31, 2014 ] [ Designated as safety issue: No ]
- To estimate the learning effect on these test at 6 months and 12 months. [ Time Frame: July 31, 2014 ] [ Designated as safety issue: No ]
|Study Start Date:||February 2008|
|Study Completion Date:||December 2013|
|Primary Completion Date:||December 2013 (Final data collection date for primary outcome measure)|
The Southeast Asia Research Collaboration with Hawaii (SEARCH) operates or collaborates on several neuroAIDS research protocols. To allow accurate interpretation of neuropsychological data, normative data that are obtained in a similar population are needed. Currently, there are limited such data available for this purpose.
The SEARCH 001 study evaluated the neurocognitive changes before and after highly active antiretroviral therapy in 30 HIV positive subjects and has also enrolled 230/300 proposed HIV-negative controls for this purpose. Normative data tables typically require many more individuals so that age and education strata can be established. We now propose to enroll up to 1000 HIV-seronegative individuals for this purpose.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00713752
|Bangkok, Thailand, 10330|
|Principal Investigator:||Victor - Valcour, M.D.||University of Hawaii|