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Speech and Language Therapy After Stroke

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT00713050
Recruitment Status : Terminated (Protocol expired; PI retired)
First Posted : July 11, 2008
Last Update Posted : June 11, 2013
Information provided by (Responsible Party):

Study Description
Brief Summary:
Our overall goal is to advance the state of functional brain imaging in aphasia, and then to apply the method to an intensive, imitation-based treatment for non-fluent aphasia.

Condition or disease Intervention/treatment
Ischemic Stroke Behavioral: Imitate Therapy

Detailed Description:
Detailed information will follow in the next progress report.

Study Design

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 34 participants
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Neurophysiological Measurement in Aphasia Treatment
Study Start Date : August 2007
Primary Completion Date : January 2012
Study Completion Date : January 2012

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Aphasia
U.S. FDA Resources

Arms and Interventions

Arm Intervention/treatment
Experimental: Experimental
Computer-based Aphasia therapy
Behavioral: Imitate Therapy
Imitation-based computer therapy
Other Name: Imitate
Active Comparator: Control
Control Arm - Healthy subjects.
Behavioral: Imitate Therapy
Imitation-based computer therapy
Other Name: Imitate

Outcome Measures

Primary Outcome Measures :
  1. Changes in scores on Western Aphasia Battery [ Time Frame: Four months ]

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  1. Single ischemic infarction in the MCA territory involving the cerebral cortex (confirmed by CT or MRI)
  2. Aphasia
  3. Visual attention and language comprehension sufficient to perform imitation fMRI tasks
  4. Right handed (prior to stroke)

Exclusion Criteria:

Exclusions to the study are people with cardiac pacemakers, claustrophobia, neurosurgical clips, or cognitive impairments too severe to permit cooperation with cognitive tasks in an MRI scanner.

Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00713050

United States, California
Solodkin/Small Brain Circuits Laboratory
Irvine, California, United States, 92697
University of California Irvine
Irvine, California, United States, 92697
Sponsors and Collaborators
University of Chicago
National Institute on Deafness and Other Communication Disorders (NIDCD)
Shirley Ryan AbilityLab
Principal Investigator: Steven Small, M.D., Ph.D. University of Chicago
More Information

Responsible Party: University of Chicago
ClinicalTrials.gov Identifier: NCT00713050     History of Changes
Other Study ID Numbers: 13785A
5R01DC007488-05 ( U.S. NIH Grant/Contract )
First Posted: July 11, 2008    Key Record Dates
Last Update Posted: June 11, 2013
Last Verified: June 2013

Keywords provided by University of Chicago:
mirror neuron

Additional relevant MeSH terms:
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Vascular Diseases
Cardiovascular Diseases